Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Mm. Hmgcl, 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Sequence ID:NM_008254
Entrez Gene ID:15356
Ensembl ID:ENSMUSG00000028672

Database Links

UniGeneEntrez GeneEnsembl GeneVegaSNPSNP: GeneViewSNP: VarViewAssemblies

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, brain, cartilage, cerebellum, cerebrum, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, limb, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, vascular
  • SAGE Expression Matrix

  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:4 D3|4 65.6 cM

Chromosomal Position (from UCSC)

Chromosomal Position:4: 135946464 - 135962608

NM_008254 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
188135502367135502454
89172135506464135506547
173280135508285135508392
281376135509771135509866
377525135511501135511649
526589135514637135514700
590778135515891135516079
779904135516697135516822
9051413135518023135518531

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5049759Full LengthBC0254403-hydroxy-3-methylglutaryl-Coenzyme A lyase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_032280  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_008254 NP_032280 P38060 EC 4.1.3.4 HMGL-like

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
S65036 AAB27965 P38060 EC 4.1.3.4
BC025440 AAH25440 P38060 EC 4.1.3.4
AK132035 BAE20956 P38060 EC 4.1.3.4
AK144768 BAE26056 Q3UMP2  
AK145251 BAE26328 P38060 EC 4.1.3.4
AK154033 BAE32329 P38060 EC 4.1.3.4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
M.musculus Hmgcl NP_032280 R.norvegicus Hmgcl 79238   NP_077362 96
H.sapiens HMGCL 3155 Gene Info NP_000182 88
A.thaliana AT2G26800 817221   NP_565629 67
A.gambiae AgaP_AGAP008717 1275567   XP_314824 65
D.melanogaster CG10399 33978   NP_609089 63
C.elegans Y71G12B.10 171738   NP_490889 52
N.crassa NCU05419 3879390   XP_963242 49

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)