Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Mm. Top2a, topoisomerase (DNA) II alpha
Sequence ID:NM_011623
Entrez Gene ID:21973
Ensembl ID:ENSMUSG00000020914

Database Links

UniGeneEntrez GeneEnsembl GeneVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:11 D|11 57.0 cM

Chromosomal Position (from UCSC)

Chromosomal Position:11: 99016592 - 99022210

 Exon Info From UCSC:
NM_011623

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5316982IncompleteBC057873topoisomerase (DNA) II alpha

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_035753  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_011623 NP_035753 Q01320 EC 5.99.1.3 DNA_gyraseB
DNA_topoisoIV
HATPase_c
DTHCT

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U01915 AAC52135 Q01320 EC 5.99.1.3
U01919 AAC52136    
BC057873 AAH57873 Q6PET9  
BC094326 AAH94326 Q52KI5  
D12513 BAA02076 Q01320 EC 5.99.1.3
AK033321 BAC28232 Q8CCE5  
AK138079 BAE23548 Q3UUS6  
AK161381 BAE36361 Q3TTG4  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
M.musculus Top2a NP_035753 R.norvegicus Top2a 360243   NP_071519 93
H.sapiens TOP2A 7153 Gene Info NP_001058 90
A.gambiae AgaP_AGAP008917 1279885   XP_319665 61
C.elegans top-2 174825   NP_496536 59
D.melanogaster Top2 35225   NP_476760 58
A.thaliana TOPII 821972   NP_189031 49
S.pombe top2 2540541   NP_595805 48
P.falciparum PF14_0316 811898   XP_001348490 47
S.cerevisiae TOP2 855636   NP_014311 46
N.crassa NCU06338 3878536   XP_962372 45

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta