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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. AURKA, aurora kinase A
Sequence ID:NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
RefSeqGene ID:NG_012133
Entrez Gene ID:6790
Ensembl ID:ENSG00000087586

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
COLON CANCERAKT1
APC
APC
AXIN2
BCL10
BUB1B
CCND1
EP300
FGFR3
FLCN
MLH3
NRAS
ODC1
PDGFRL
PIK3CA
PIK3CA
PLA2G2A
PTPRJ
SMAD7
TLR2
TLR4
TP53
TP53

Cytogenetic Location (from UniGene)

Cytogenetic Location:20q13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:20: 54945213 - 54963253

 Exon Info From UCSC:
NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3051177Full LengthBC002499aurora kinase A
3456017Full LengthBC001280aurora kinase A
3532438Full LengthBC006423aurora kinase A
4449474Full LengthBC027464aurora kinase A

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_940839  NP_940836  NP_940837  NP_940838  NP_003591  NP_940835  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_003600 NP_003591   Pkinase
Pkinase_Tyr
NM_198433 NP_940835   Pkinase
Pkinase_Tyr
NM_198434 NP_940836   Pkinase
Pkinase_Tyr
NM_198435 NP_940837   Pkinase
Pkinase_Tyr
NM_198436 NP_940838   Pkinase
Pkinase_Tyr
NM_198437 NP_940839   Pkinase
Pkinase_Tyr

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF008551 AAC12708 O14965 EC 2.7.11.1
AF011468 AAC63902 O14965 EC 2.7.11.1
BC001280 AAH01280 O14965 EC 2.7.11.1
BC002499 AAH02499 O14965 EC 2.7.11.1
BC006423 AAH06423 O14965 EC 2.7.11.1
BC027464 AAH27464 O14965 EC 2.7.11.1
DQ891270 ABM82196    
DQ894458 ABM85384    
D84212 BAA23592 O14965 EC 2.7.11.1
AK312776 BAG35640 B2R6Z3  
AK301769 BAG63228 B4DX16  
AM392948 CAL37826 O14965 EC 2.7.11.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens AURKA NP_003591 R.norvegicus Aurka 261730   NP_695208 85
M.musculus Aurka 20878 Gene Info NP_035627 84
A.thaliana AUR2 817129   NP_180159 66
A.thaliana AUR1 829419   NP_195009 62
S.pombe ark1 3361036   NP_001018849 62
C.elegans air-2 172268   NP_491714 58
N.crassa NCU00108 3873395   XP_957232 58
D.melanogaster aur 41446   NP_476749 54
S.cerevisiae IPL1 855892   NP_015115 45

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta