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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TSC2, tuberous sclerosis 2
Sequence ID:NM_000548
NM_001077183
NM_001114382
NM_021055
NM_021056
RefSeqGene ID:NG_005895
Entrez Gene ID:7249
Ensembl ID:ENSG00000103197

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LYMPHANGIOLEIOMYOMATOSISTSC1
TSC2 ANGIOMYOLIPOMAS, RENAL, MODIFIER OFIFNG
TUBEROUS SCLEROSIS-1IFNG
TSC1

Cytogenetic Location (from UniGene)

Cytogenetic Location:16p13.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:16: 2097989 - 2138703

 Exon Info From UCSC:
NM_000548
NM_001077183
NM_001114382

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
8860381Full LengthBC150300tuberous sclerosis 2
3687567IncompleteBC046929tuberous sclerosis 2
3687776IncompleteBC025364tuberous sclerosis 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000539  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000548 NP_000539 P49815 Rap_GAP
Tuberin
NM_001077183 NP_001070651    
NM_001114382 NP_001107854    

Related Sequences

 
mRNAGenPeptSwissProt
S82474 AAB37376  
BC025364 AAH25364 P49815
BC046929 AAH46929 P49815
BC150300 AAI50301 P49815
AB210000 BAE06082 P49815
AK094152 BAG52831 B3KSR9
AK125096 BAG54139 B3KWH7
AK295672 BAG58530 B4DIL8
AK295728 BAG58569 P49815
AK299343 BAG61344 P49815
X75621 CAA53287 P49815
BX647816 CAI46010 Q5HYF7

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TSC2 NP_000539 M.musculus Tsc2 22084 Gene Info NP_035777 92
R.norvegicus Tsc2 24855   NP_036812 91
A.gambiae AgaP_AGAP011123 1270802   XP_309523 38
D.melanogaster gig 40201   NP_524177 36

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta