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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TGFBR2, transforming growth factor, beta receptor II (70/80kDa)
Sequence ID:NM_001024847
NM_003242
RefSeqGene ID:NG_007490
Entrez Gene ID:7048
Ensembl ID:ENSG00000163513

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 6 
ESOPHAGEAL CANCER, SOMATICDEC1
DLEC1
LZTS1
RNF6
WWOX
LOEYS-DIETZ SYNDROME, TYPE 1B 
LOEYS-DIETZ SYNDROME, TYPE 2B 

Cytogenetic Location (from UniGene)

Cytogenetic Location:3p22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 30691910 - 30713307

 Exon Info From UCSC:
NM_001024847
NM_003242

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5287742IncompleteBC040499transforming growth factor, beta receptor II (70/80kDa)
100016037BC152840transforming growth factor, beta receptor II (70/80kDa)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003233  NP_001020018  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001024847 NP_001020018     Pkinase
Pkinase_Tyr
NM_003242 NP_003233 P37173 EC 2.7.11.30 Pkinase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M85079 AAA61164 P37173 EC 2.7.11.30
BC152840 AAI52841    
D28131 BAA05673 P37173 EC 2.7.11.30
AK314102 BAG36796 A3QNQ0  
AK300383 BAG62117 P37173 EC 2.7.11.30
AK304404 BAG65238 B4E2S6  
AJ786388 CAH10151 Q6A176  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TGFBR2 NP_001020018 M.musculus Tgfbr2 21813 Gene Info NP_033397 91
R.norvegicus Tgfbr2 81810   NP_112394 90

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta