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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HLA-B, major histocompatibility complex, class I, B
Sequence ID:NM_005514
RefSeqGene ID:NG_023187
Entrez Gene ID:3106
Ensembl ID:ENSG00000234745

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
HYPERSENSITIVITY SYNDROME, CARBAMAZEPINE-INDUCED, SUSCEPTIBILITYTOHLA-A
HLA-A
SPONDYLOARTHROPATHYHLA-A
HLA-A

Cytogenetic Location (from UniGene)

Cytogenetic Location:6p21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:6: 31322259 - 31324935

NM_005514 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
74313132164831322072
4324793132225531322302
4805123132240931322441
5136293132288331322999
6309053132309331323368
90611813132394331324218
118214513132446431324733
145215783132486231324988

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4344323Full LengthBC013187major histocompatibility complex, class I, B
2966516IncompleteBC007243major histocompatibility complex, class I, B

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005505  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001243042 NP_001229971    
NM_002117 NP_002108 Q6R739
Q95HC2
P10321
MHC_I
MHC_I_C
C1-set
NM_005514 NP_005505 P01889 MHC_I
MHC_I_C
C1-set

Related Sequences

 
mRNAGenPeptSwissProt
M24031 AAA00027 Q8SNA8
U03859 AAA03601 P30464
M77774 AAA03686 P30492
Q54A64
M77778 AAA03687 P30493
Q3ZV43
M77776 AAA03689 P30495
U07230 AAA17037 Q29645
U06862 AAA17373 Q29644
L09735 AAA18249 Q29941
U03027 AAA18902 P30464
U11262 AAA19922 Q29654
Q29653
Q29657
U11264 AAA19924 Q29654
Q29653
Q29657
U11265 AAA19925 O19626
U11266 AAA19926 Q29655
Q29656
U11267 AAA19927 P18463
U11268 AAA19928 Q29655
Q29656
U11269 AAA19929 Q29654
Q29653
Q29657
J00192 AAA36217 Q29923
L09736 AAA36224 Q04826
M32317 AAA36230 P01889
M32318 AAA36231 P18465
M32319 AAA36232 P18464
Q546B1
M32320 AAA36233 P18463
M28160 AAA36235 Q29963
U09853 AAA50217 P10321
U01848 AAA50577 Q31602
M11886 AAA52665 P10321
M26712 AAA52666 O19677
U04787 AAA53175 Q31612
M28204 AAA53257 O19691
M28203 AAA53258 P30464
M28207 AAA53259 P10321
U17572 AAA56782 Q29674
L15005 AAA56832 Q29911
L22027 AAA56834 Q29943
L11666 AAA56835 Q29981
L11604 AAA56836 P30464
L11603 AAA56837 Q29985
L19937 AAA56838 Q30172
M28205 AAA57145 Q29938
M28206 AAA57258 Q29963
M83193 AAA58628 P30464
M64257 AAA59607 Q29930
Q29928
M64253 AAA59609 Q29930
Q29928
M12678 AAA59614 Q29934
M15470 AAA59619 P30481
L07743 AAA59621 Q29940
M16102 AAA59622 P01889
M84380 AAA59629 P30486
M75138 AAA59630 P30464
M84382 AAA59632 P30464
Q7YNX1
M27540 AAA59638 Q29948
M64254 AAA59641 Q29951
M24096 AAA59654 Q29958
M24097 AAA59656 Q29960
M24097 AAA59657 Q29960
M24033 AAA59665 P30484
L07950 AAA59683 Q08173
M84171 AAA59685 Q7YNW6
P30499
M84172 AAA59686 Q7YQB3
P04222
M84173 AAA59687 P30505
M84174 AAA59688 P30505
Q546I7
M12679 AAA59699 Q14838
M26429 AAA59701 P30499
M26430 AAA59703 P30501
M26431 AAA59704 Q29988
M84386 AAA59705 Q5D1W8
P30504
M21963 AAA59847 P30508
M83195 AAA60305 Q30191
M83191 AAA61268 Q30206
M83194 AAA61296 Q30207
M83192 AAA61297 O19781
L33922 AAA65639 P01889
L36591 AAA73509 Q95365
U32660 AAA75321 Q29707
U32661 AAA75550 Q29708
Q29701
Q860Q9
U34810 AAA75592 Q29716
U35431 AAA81336 Q31602
U04244 AAA87397 Q29637
U04245 AAA87398 P01889
M99389 AAA88088 Q53YP1
P04222
M99390 AAA88089 P04222
U29057 AAA91229 P01889
U21052 AAA92563 P01889
U21053 AAA92564 P01889
U06695 AAA92995 P30508
Q96FQ5
U06696 AAA92996 P30508
Q96FQ5
U06697 AAA92997 Q29642
U32678 AAA93171 Q29710
U50710 AAA93482 Q29748
L76935 AAA96268 Q29760
L76930 AAA96269 O19650
L24373 AAA96733 Q31612
U31971 AAA98506 Q29705
U17107 AAB02169 Q29669
U58110 AAB02267 Q29750
U70528 AAB16918 P30464
Q7YNX1
U70529 AAB16919 Q29644
U30904 AAB19241 Q29700
U31334 AAB19242 Q29708
Q29701
Q860Q9
U80945 AAB39257 P79549
U64801 AAB40632 P30481
U74386 AAB41720 P30460
U74387 AAB41721 P79543
U09864 AAB41946 Q29932
L42345 AAB59610 Q29849
L76932 AAB59615 Q29761
L76933 AAB59616 Q29763
Q95IC9
U16298 AAB60349 O02962
Q29666
U16309 AAB60350 Q29667
U18659 AAB60357 O19189
U18660 AAB60358 Q29676
U18661 AAB60359 Q29677
U28759 AAB60367 Q29694
U30936 AAB61773 O19755
U62824 AAB67322 Q95604
AF004370 AAB69158 O19508
U36392 AAB70114 O19790
U39088 AAB80796 Q29733
AF022783 AAB81828 O19589
U88407 AAC16437 P30480
AF016641 AAC17467 O19554
U41420 AAC32742 O78179
U41386 AAC32743 P30510
U57966 AAC32744 Q95346
U34618 AAC35422 Q8SP59
O78183
U34619 AAC35423 Q9TQJ2
Q29859
O78182
L17005 AAC37548 Q29836
L32862 AAC37572 Q29844
L37881 AAC41929 Q29932
L37880 AAC41941 Q31610
L41925 AAC41979 P18464
AF026218 AAC42275 O78189
U29880 AAC50445 Q29699
U91179 AAC51396  
U40498 AAD00010 Q95365
U96942 AAD00845 O98221
AF033351 AAD01961 Q9TQB8
U57028 AAD11469 Q9TNN7
Q5RIP0
S55521 AAD13875 Q30210
S74115 AAD14147 Q29658
AF168611 AAD50823 Q9TNN7
AF170577 AAD50968 Q9TPW6
AF189017 AAF01052 P01889
L38251 AAF26750 Q9MY34
AF130734 AAF27539 Q9MYI6
U09912 AAF70855 Q31610
AY007140 AAG02001 P30493
Q3ZV43
AF298582 AAG16246 Q9GJ36
BC002463 AAH02463 O78179
BC007243 AAH07243 P18464
BC007814 AAH07814 Q6R739
Q95HC2
P10321
BC008457 AAH08457 Q96QL3
BC010542 AAH10542 Q96FQ5
BC013187 AAH13187 Q96DW9
BC033293 AAH33293 O19617
BC091497 AAH91497 Q5SS57
P30460
AF405691 AAL03994 Q95HN1
AY040668 AAL09919 Q95HL2
AF389378 AAL26324 P18463
AF436090 AAL30409 Q95HM5
AF436091 AAL30410 Q95HM4
AF436092 AAL30411 Q95HM3
AF436093 AAL30412 Q95HM2
AF436094 AAL30413 Q95HM1
AF436095 AAL30414 Q95HM0
AF436096 AAL30415 Q95HL9
AF436098 AAL30417 Q95HL7
Q95IE1
L63544 AAL31312 Q8HWP9
Q9MYD1
Q8WZ43
Q4ZIL8
Q8WLR7
Q4GWZ9
L76639 AAL40066 Q8WLR3
L77114 AAL40067 Q9TPQ8
Q9GJG4
Q8WLR2
L76252 AAL40070 Q8WWJ0
L79937 AAL40071 Q58P07
Q8WLQ8
Q7YP30
Q4L1J7
L79935 AAL40072 Q8WLR0
L79936 AAL40073 Q8SNA6
Q8WLQ9
L40562 AAL77528 Q8SP66
L42545 AAL77529 Q8SP65
L47338 AAL77530 O19644
Q53ZP0
Q9TPU4
Q8SP64
O19746
L47985 AAL77531 Q9TQG4
Q5EJW3
Q8SP62
O19747
L47984 AAL77532 Q8SP63
Q9MYE8
Q9MY86
Q8HWN9
L47986 AAL77533 Q8SP61
Q3LZI1
L48400 AAL77534 Q9TPM4
Q8SP60
Q9GIX5
Q9TQJ4
O78122
L49343 AAL77535 Q8TE31
L49342 AAL77536 Q8TE32
L49341 AAL77537 Q8SP59
O78183
AY102648 AAM50088 Q8MGZ8
AF196489 AAM76870 Q95HN1
AY221104 AAO34409 Q861E8
AY569160 AAS79490 Q6Q0M4
AY732487 AAV33126 Q5UGI4
DQ336696 ABC59613 Q2LC92
DQ336697 ABC59614 Q2LC91
DQ336698 ABC59615 Q2LC90
DQ891896 ABM82822  
DQ895082 ABM86008  
EU048339 ABW16863 B4XKD1
HM989017 ADT80734 E7CZN2
D25275 BAA04965 P30466
D31816 BAA06603 Q29767
D38526 BAA07531 Q6R739
Q95HC2
P10321
D49552 BAA08500 Q7YQB2
P10321
D49819 BAA08625 Q6R739
Q95HC2
P10321
D50290 BAA08821 P30461
D50291 BAA08822 Q546P4
P30461
D50292 BAA08823 P30464
D50293 BAA08824 P30464
D50294 BAA08825 P30464
D50295 BAA08826 Q29911
D50296 BAA08827 Q95346
D50300 BAA08829 Q29940
D83029 BAA11747 P79497
D83043 BAA11753 P79612
D87665 BAA13429 Q95353
D64145 BAA19531 P30499
D64146 BAA19532 P30508
D64147 BAA19533 O19657
D64148 BAA19534 Q9TNN7
D64150 BAA19535 O19653
D64151 BAA19536 O19655
D64152 BAA19537 P30508
AB008102 BAA22916 Q5QT34
P10319
D50853 BAA32610 P04222
D50852 BAA32611 Q7YNW6
D50854 BAA32612 Q53X46
D83030 BAA32613 O78164
D83741 BAA32615 P30508
AK292226 BAF84915 A8K861
AK313911 BAG36634 P01889
AK124160 BAG54016 B3KW54
AK300685 BAG62368 B4DUK6
AK301283 BAG62842 B4DVY0
AK304527 BAG65328 B4E316
AJ002675 CAA05678 O19644
Q53ZP0
Q9TPU4
Q8SP64
O19746
AJ002676 CAA05679 Q7JFI6
Q6J0S1
O19645
AJ002677 CAA05680 O19519
O19646
O19616
AJ003063 CAA05834 O19648
AJ005199 CAA06438 Q9TNU1
AJ010748 CAA09340 Q9TNN7
Q5RIP0
AJ010749 CAA09341 P10321
AJ223602 CAA11468 O78043
V00527 CAA23786 Q29843
X58536 CAA41427 Q5D1W8
P30504
X61708 CAA43877 P30498
X61709 CAA43878 P30464
X61710 CAA43879 P30483
X64366 CAA45718 P30481
X64454 CAA45785 P01889
X70856 CAA50209 P30508
Q546I6
X70857 CAA50210 Q29963
P30508
Q5QT33
X75953 CAA53566 Q29853
X76189 CAA53783 Q29960
X77658 CAA54739 Q31612
X82122 CAA57634 P30508
Q96FQ5
X83394 CAA58313 Q7YQB2
P10321
X83401 CAA58317 Q29856
X90390 CAA62035 Q31610
X90391 CAA62036 P30481
X91749 CAA62864 P01889
X96473 CAA65327 Q95364
X97321 CAA65986 P10321
X98742 CAA67294 Q95604
X99704 CAA68035 P30508
Y07710 CAA68983 Q7JFI6
Q6J0S1
O19645
Y07824 CAA69157 Q95363
Q29759
Y08994 CAA70198 P18464
Y10520 CAA71531 Q95604
Y11843 CAA72592 P30508
Y13029 CAA73474 Q9GJN3
O02874
Y13567 CAA73901 O19782
Z15143 CAA78849 P18464
Z15144 CAA78850 P30505
Q53X46
Z33459 CAA83881 Q29866
Z46808 CAA86838 P18464
Z46809 CAA86839 P30499
Z46810 CAA86840 P10321
Z83247 CAB05845 P30508
AJ131118 CAB37868 P30481
AJ276427 CAB88037 Q9MY47
AJ440716 CAD29433 Q8SNB1
AJ537578 CAD61205 Q861B1
AJ634528 CAG25407 Q5W3L5
BX647315 CAI46008 Q5HYL2
AM237285 CAJ86551 Q1XDY2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HLA-B NP_005505 M.musculus H2-Gs10 436493   NP_001137161 70
M.musculus Gm8909 667977   NP_001074501 69
M.musculus H2-Q2 15013 Gene Info NP_034522 69
M.musculus H2-Q9 110558   XP_003085174 69
M.musculus H2-Q1 15006 Gene Info NP_034520 68
M.musculus Gm10499 69717 Gene Info XP_003085179 68
M.musculus H2-Q6 110557 Gene Info NP_997531 68
M.musculus H2-Bl 14963 Gene Info NP_032225 66

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)