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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TYK2, tyrosine kinase 2
Sequence ID:NM_003331
RefSeqGene ID:NG_007872
Entrez Gene ID:7297
Ensembl ID:ENSG00000105397

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
TYROSINE KINASE 2 DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:19p13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 10461209 - 10491277

 Exon Info From UCSC:
NM_003331

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4591726Full LengthBC014243tyrosine kinase 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_003322  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_003331 NP_003322 P29597 EC 2.7.10.2 Pkinase
Pkinase_Tyr

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC014243 AAH14243 P29597 EC 2.7.10.2
DQ892692 ABM83618    
DQ895955 ABM86881    
AK222672 BAD96392 Q53HA9  
AK303627 BAG64635 B4E123  
X54637 CAA38449 P29597 EC 2.7.10.2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TYK2 NP_003322 R.norvegicus Tyk2 100361294   XP_002729920 81
M.musculus Tyk2 54721 Gene Info NP_061263 80

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta