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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
Sequence ID:NM_001098272
NM_002130
Entrez Gene ID:3157
Ensembl ID:ENSG00000112972

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data


Cytogenetic Location (from UniGene)

Cytogenetic Location:5p14-p13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 43298926 - 43313510

 Exon Info From UCSC:
NM_001098272
NM_002130

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4443624Full LengthBC0835143-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
2819708IncompleteBC0002973-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)
3677631IncompleteBC0822343-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble)

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001098272 NP_001091742 Q01581 EC 2.3.3.10  
NM_002130 NP_002121 Q5XJ04   HMG_CoA_synt_N
HMG_CoA_synt_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
L25798 AAA62411 Q01581 EC 2.3.3.10
BC000297 AAH00297 Q01581 EC 2.3.3.10
BC083514 AAH83514 Q5XJ04  
BT007302 AAP35966 Q01581 EC 2.3.3.10
AK095492 BAC04559 Q8N995  
AK315593 BAG37965 Q01581 EC 2.3.3.10
X66435 CAA47061 Q01581 EC 2.3.3.10

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HMGCS1 NP_002121 R.norvegicus Hmgcs1 29637   NP_058964 95
M.musculus Hmgcs1 208715 Gene Info NP_666054 95
M.musculus LOC100040592 100040592   XP_001475239 95
D.melanogaster Hmgs 44154   NP_725567 65
A.gambiae AgaP_AGAP005847 1276514   XP_315872 64
N.crassa NCU03922 3873746   XP_957561 53
S.cerevisiae ERG13 854913   NP_013580 51
A.thaliana MVA1 826788   NP_192919 50
S.pombe hcs1 2543141   NP_593859 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta