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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. EIF2B1, eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
Sequence ID:NM_001414
RefSeqGene ID:NG_015862
Entrez Gene ID:1967
Ensembl ID:ENSG00000111361

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKOENCEPHALOPATHY WITH VANISHING WHITE MATTEREIF2B2
EIF2B3
EIF2B4
EIF2B5

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q24.31Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 124111247 - 124118313

NM_001414 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
18914124105570124106466
9151040124107182124107307
10411116124109333124109408
11171185124110971124111039
11861298124111590124111702
12991415124114715124114831
14161552124114943124115079
15531654124116891124116992
16551886124118091124118322

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6148834Full LengthBC103763eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
40030987Full LengthBC104188eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa
40030991Full LengthBC104189eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001405  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001414 NP_001405 Q14232 IF-2B

Related Sequences

 
mRNAGenPeptSwissProt
BC103763 AAI03764 Q14232
BC104188 AAI04189 Q14232
BC104189 AAI04190 Q14232
AK294815 BAG57931 B4DGX0
X95648 CAA64950 Q14232
CR456831 CAG33112 Q14232

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens EIF2B1 NP_001405 M.musculus Eif2b1 209354 Gene Info NP_663346 94
R.norvegicus Eif2b1 64514   NP_742026 93
A.gambiae AgaP_AGAP012799 1268536   XP_307097 56
D.melanogaster eIF2B-alpha 43549   NP_651752 51
A.gambiae AgaP_AGAP003650 1274318   XP_313420 50
A.gambiae AgaP_AGAP012611 1268479   XP_307038 47
A.thaliana AT1G72340 843566   NP_565041 47
A.thaliana AT1G53900 841828   NP_564646 45
A.thaliana AT1G53880 841825   NP_564643 45
S.cerevisiae GCN3 853896   NP_012951 44
C.elegans ZK1098.4 176348   NP_499106 43
S.pombe SPCC11E10.07c 2539154   NP_588203 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta