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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. SHMT2, serine hydroxymethyltransferase 2 (mitochondrial)
Sequence ID:NM_001166356
RefSeqGene ID:NG_029163
Entrez Gene ID:6472
Ensembl ID:ENSG00000182199

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssemblies

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q12-q14Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 57623493 - 57628509

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3863368Full LengthBC013677serine hydroxymethyltransferase 2 (mitochondrial)
4139001Full LengthBC011911serine hydroxymethyltransferase 2 (mitochondrial)
5499481Full LengthBC032584serine hydroxymethyltransferase 2 (mitochondrial)
5521082Full LengthBC044211serine hydroxymethyltransferase 2 (mitochondrial)
3530697IncompleteBC008711serine hydroxymethyltransferase 2 (mitochondrial)
30378499IncompleteBC091501serine hydroxymethyltransferase 2 (mitochondrial)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005403  

Protein Infomation

NM_001166356 NP_001159828      
NM_001166357 NP_001159829      
NM_001166358 NP_001159830      
NM_001166359 NP_001159831      
NM_005412 NP_005403 P34897 EC SHMT

Related Sequences

L11932 AAA63258 P34897 EC
BC011911 AAH11911 P34897 EC
BC013677 AAH13677 P34897 EC
BC032584 AAH32584 P34897 EC
BC044211 AAH44211 P34897 EC
BC091501 AAH91501 Q5BJF5  
BT006866 AAP35512 P34897 EC
DQ891309 ABM82235    
DQ894430 ABM85356    
AK223555 BAD97275 Q53ET4  
AK295941 BAG58725 B4DJ63  
AK296183 BAG58915 B4DJQ3  
AK297173 BAG59666 B4DLV4  
AK298231 BAG60500 B4DP88  
AK301339 BAG62887 B4DW25  
AK301443 BAG62969 B4DWA7  
AK303827 BAG64774 B4E1G2  
AK315916 BAH14287 P34897 EC
BX647711 CAI46021 Q5HYG8  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens SHMT2 NP_005403 M.musculus Shmt2 108037 Gene Info NP_082506 94
R.norvegicus Shmt2 299857   NP_001008323 94
A.thaliana SHM2 832736   NP_851081 60
S.pombe SPAC24C9.12c 2542651   NP_594037 58
N.crassa NCU02274 3876040   XP_959918 58
S.cerevisiae SHM2 850747   NP_013159 57

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)