Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TPH2, Tryptophan hydroxylase 2
Sequence ID:NM_173353
RefSeqGene ID:NG_008279
Entrez Gene ID:121278
Ensembl ID:ENSG00000139287

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MAJOR DEPRESSIVE DISORDER, RESPONSE TO CITALOPRAM THERAPY INFKBP5
HTR2A

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q21.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 72332756 - 72359270

 Exon Info From UCSC:
NM_173353

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40083876Full LengthBC114499tryptophan hydroxylase 2
40083878Full LengthBC114442tryptophan hydroxylase 2

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_775489  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_173353 NP_775489 Q8IWU9 EC 1.14.16.4 Biopterin_H
ACT

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
BC114442 AAI14443 Q14CC5  
BC114499 AAI14500 Q8IWU9 EC 1.14.16.4
AY098914 AAM28946 Q8IWU9 EC 1.14.16.4
AK094614 BAC04385 Q8N1X9  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TPH2 NP_775489 R.norvegicus Tph2 317675   NP_776211 94
M.musculus Tph2 216343 Gene Info NP_775567 93

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)