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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TREX1, three prime repair exonuclease 1
Sequence ID:NM_007248
NM_016381
NM_033629
NM_033627
NM_033628
RefSeqGene ID:NG_009820
Entrez Gene ID:11277
Ensembl ID:ENSG00000213689

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssemblies

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
?SYSTEMIC LUPUS ERYTHEMATOSUS, OR PROTECTION AGAINSTBANK1
C4A
C4A
DNASE1
DNASE1
FASLG
FCGR2B
FCGR3A
ITGAX
PDCD1
PTPN22
STAT4
STAT4
AICARDI-GOUTIERES SYNDROME 1, DOMINANT AND RECESSIVE 
CHILBLAIN LUPUS 
VASCULOPATHY, RETINAL, WITH CEREBRAL LEUKODYSTROPHY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:3p21.31Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:3: 48507209 - 48509044

 Exon Info From UCSC:
NM_016381
NM_033629

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100064020Full LengthBC160084three prime repair exonuclease 1
5109215IncompleteBC019863three prime repair exonuclease 1

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_007248 NP_009179      
NM_016381 NP_057465 Q9NSU2 EC 3.1.11.2  
NM_033629 NP_338599      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF151105 AAD48774 Q9NSU2 EC 3.1.11.2
BC023630 AAH23630 Q9NSU2 EC 3.1.11.2
BC160084 AAI60084    
BT020052 AAV38855 Q5TZT0  
BT020053 AAV38856 Q5TZT0  
EU832715 ACE87047    
EU832638 ACE87729    
AK315196 BAG37636 Q9NSU2 EC 3.1.11.2
AJ243797 CAB50866 Q9NSU2 EC 3.1.11.2
CR457119 CAG33400 Q6IAN5  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TREX1 NP_057465 R.norvegicus Trex1 100049583   NP_001020160 75
M.musculus Trex1 22040 Gene Info NP_001012236 74

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta