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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. SOS1, son of sevenless homolog 1 (Drosophila)
Sequence ID:NM_005633
RefSeqGene ID:NG_007530
Entrez Gene ID:6654
Ensembl ID:ENSG00000115904

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
FIBROMATOSIS, GINGIVAL 
NOONAN SYNDROME 4 

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 39212826 - 39262438

 Exon Info From UCSC:
NM_005633

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100014292BC140215son of sevenless homolog 1 (Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005624  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005633 NP_005624 Q07889 Histone
PH
RasGEF
RasGEF_N
RhoGEF

Related Sequences

 
mRNAGenPeptSwissProt
L13857 AAA35913 Q07889
BC140215 AAI40216  
AB209140 BAD92377 Q59GG9
AK290228 BAF82917 Q07889
AK301960 BAG63374 B4DXG2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens SOS1 NP_005624 M.musculus Sos1 20662 Gene Info NP_033257 98
R.norvegicus Sos1 313845   NP_001094186 98
A.gambiae AgaP_AGAP009180 1280136   XP_319944 49
D.melanogaster Sos 34790   NP_476597 48
C.elegans sos-1 178846   NP_504235 38

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta