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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. F2, coagulation factor II (thrombin)
Sequence ID:NM_000506
RefSeqGene ID:NG_008953
Entrez Gene ID:2147
Ensembl ID:ENSG00000180210

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
CEREBRAL INFARCTIONALOX5AP
F5
NOS3
PRKCH
DYSPROTHROMBINEMIA 
PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITYTO, 2 
THROMBOPHILIA DUE TO THROMBIN DEFECTF13A1
HABP2
MTHFR
MTHFR

Cytogenetic Location (from UniGene)

Cytogenetic Location:11p11Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 46740754 - 46761055

 Exon Info From UCSC:
NM_000506

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6283420Full LengthBC051332coagulation factor II (thrombin)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000497  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000506 NP_000497 P00734 EC 3.4.21.5 Kringle
Trypsin
Gla

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M33031 AAA60220 Q15253  
BC051332 AAH51332 P00734 EC 3.4.21.5
AY344793 AAR08142 Q69EZ8  
AY344794 AAR08143 Q69EZ7  
EU832742 ACE87074    
EU832664 ACE87755    
AK222775 BAD96495 P00734 EC 3.4.21.5
AK222777 BAD96497 P00734 EC 3.4.21.5
AK312965 BAG35804 P00734 EC 3.4.21.5
AK293326 BAG56844 B4DDT3  
AK303747 BAG64719 P00734 EC 3.4.21.5
V00595 CAA23842 P00734 EC 3.4.21.5
AJ972449 CAJ01369 P00734 EC 3.4.21.5

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens F2 NP_000497 M.musculus F2 14061 Gene Info NP_034298 82
R.norvegicus F2 29251   NP_075213 81

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta