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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. GCLC, Glutamate-cysteine ligase, catalytic subunit
Sequence ID:NM_001498
NM_001197115
RefSeqGene ID:NG_012071
Entrez Gene ID:2729
Ensembl ID:ENSG00000001084

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
HEMOLYTIC ANEMIA DUE TO GAMMA-GLUTAMYLCYSTEINE SYNTHETASE DEFICIENCY 
MYOCARDIAL INFARCTIONESR1
F13A1
F7
GCLM
ITGB3
LGALS2
LRP8
LTA
MIAT
OLR1
PSMA6
THBD
TNFSF4

Cytogenetic Location (from UniGene)

Cytogenetic Location:6p12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:6: 53362139 - 53409830


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6052162Full LengthBC039894glutamate-cysteine ligase, catalytic subunit

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001489  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001197115 NP_001184044      
NM_001498 NP_001489 P48506 EC 6.3.2.2 GCS

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M90656 AAA58499 P48506 EC 6.3.2.2
BC022487 AAH22487 P48506 EC 6.3.2.2
BC039894 AAH39894 P48506 EC 6.3.2.2
EU832402 ACE86887    
EU832317 ACE87574    
AB262176 BAE97618 Q14TF0  
AK313480 BAG36264 Q14TF0  
AK304288 BAG65146 B4E2I4  
AB516284 BAJ21361 E1CEI4  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens GCLC NP_001489 M.musculus Gclc 14629 Gene Info NP_034425 95
R.norvegicus Gclc 25283   NP_036947 94
A.gambiae AgaP_AGAP001512 1281664   XP_321610 64
D.melanogaster Gclc 53581   NP_525005 60
C.elegans gcs-1 174438   NP_495927 56
S.pombe gcs1 2541881   NP_593031 54
N.crassa NCU01157 3877703   XP_961523 51
S.cerevisiae GSH1 853344   NP_012434 48

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)