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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. IL6, interleukin 6 (interferon, beta 2)
Sequence ID:NM_000600
RefSeqGene ID:NG_011640
Entrez Gene ID:3569
Ensembl ID:ENSG00000136244

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
CROHN DISEASE-ASSOCIATED GROWTH FAILUREDEFB4A
DLG5
IL23R
NOD2
SLC22A4
DIABETES MELLITUS, NON-INSULIN-DEPENDENTABCC8
AKT2
CDKAL1
ENPP1
GCGR
GCK
GPD2
HMGA1
HMGA1
HNF1A
HNF1B
HNF4A
IGF2BP2
IRS1
IRS2
KCNJ11
LIPC
MAPK8IP1
MTNR1B
NEUROD1
NEUROD1
NEUROD1
PAX4
PDX1
PPARG
PTPN1
RETN
SLC2A4
SLC30A8
TCF7L2
VEGFA
WFS1
WFS1
INTRACRANIAL HEMORRHAGE IN BRAIN CEREBROVASCULAR MALFORMATIONS 
KAPOSISARCOMA 
OSTEOPOROSISCALCR
COL1A1
COL1A2
LRP5
PDLIM4
VDR
RHEUMATOID ARTHRITIS, SYSTEMIC JUVENILEMIF

Cytogenetic Location (from UniGene)

Cytogenetic Location:7p21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:7: 22766818 - 22770076

NM_000600 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
11352276676522766899
1363262276706222767252
3274402276831122768424
4415872276913222769278
58811822277102422771618

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3884652Full LengthBC015511interleukin 6 (interferon, beta 2)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000591  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000600 NP_000591 P05231
Q75MH2
IL6

Related Sequences

 
mRNAGenPeptSwissProt
M14584 AAA52728 P05231
Q75MH2
M18403 AAA52729 P05231
Q75MH2
M29150 AAA59154 P05231
Q75MH2
M54894 AAC41704 P05231
Q75MH2
S56892 AAD13886 P05231
Q75MH2
BC015511 AAH15511 P05231
Q75MH2
BT019748 AAV38553 P05231
Q75MH2
BT019749 AAV38554 P05231
Q75MH2
DQ891463 ABM82389  
DQ894639 ABM85565  
AK298013 BAG60317 B4DNQ5
AK298077 BAG60365 B4DNV3
AK301141 BAG62733 B4DVM1
A09363 CAA00839 P05231
Q75MH2
X04403 CAA27991 P05231
X04430 CAA28026 P05231
Q75MH2
X04602 CAA28268 P05231
Q75MH2
CR450296 CAG29292 P05231
Q75MH2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens IL6 NP_000591 R.norvegicus Il6 24498   NP_036721 42
M.musculus Il6 16193 Gene Info NP_112445 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta