Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. APOE, apolipoprotein E
Sequence ID:NM_000041
RefSeqGene ID:NG_007084
Entrez Gene ID:348
Ensembl ID:ENSG00000130203

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer Aberrations

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, synovium, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
AGE-RELATED MACULOPATHYC2
CFB
CFHR1
CFHR3
CX3CR1
HMCN1
PLEKHA1
PLEKHA1
TLR3
ALZHEIMER DISEASE-2 
LIPOPROTEIN GLOMERULOPATHY 
SEA-BLUE HISTIOCYTE DISEASE 

Cytogenetic Location (from UniGene)

Cytogenetic Location:19q13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 45409052 - 45410583

NM_000041 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
1604540903845409097
611264540985845409923
1273194541101645411208
32011794541178945412648

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3355712Full LengthBC003557apolipoprotein E

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000032  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000041 NP_000032 P02649 Apolipoprotein

Related Sequences

 
mRNAGenPeptSwissProt
M12529 AAB59518 P02649
K00396 AAB59546 P02649
BC003557 AAH03557 P02649
DQ892548 ABM83474  
DQ895759 ABM86685  
AK314898 BAG37412 P02649
X00199 CAA25017 Q6LBZ1
Z70760 CAA94806 Q6LA97

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens APOE NP_000032 M.musculus Apoe 11816 Gene Info NP_033826 73
R.norvegicus Apoe 25728   NP_620183 72

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)