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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MTHFD1, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
Sequence ID:NM_005956
RefSeqGene ID:NG_012450
Entrez Gene ID:4522
Ensembl ID:ENSG00000100714

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
NEURAL TUBEDEFECTS, FOLATE-SENSITIVEMTHFR
MTHFR
MTR
MTRR

Cytogenetic Location (from UniGene)

Cytogenetic Location:14q24Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:14: 64855045 - 64926722

 Exon Info From UCSC:
NM_005956

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3508998Full LengthBC009806methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
5788176Full LengthBC050420methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
3344724IncompleteBC001014methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005947  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_005956 NP_005947   THF_DHG_CYH
FTHFS
THF_DHG_CYH_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J04031 AAA59574 P11586 EC 1.5.1.5
EC 6.3.4.3
EC 3.5.4.9
BC001014 AAH01014 P11586 EC 1.5.1.5
EC 6.3.4.3
EC 3.5.4.9
BC009806 AAH09806 P11586 EC 1.5.1.5
EC 6.3.4.3
EC 3.5.4.9
BC050420 AAH50420 P11586 EC 1.5.1.5
EC 6.3.4.3
EC 3.5.4.9
DQ893634 ABM84560    
DQ896853 ABM87852    
AK312361 BAG35279 P11586 EC 1.5.1.5
EC 6.3.4.3
EC 3.5.4.9
AK302747 BAH13795 B7Z809  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MTHFD1 NP_005947 R.norvegicus Mthfd1 64300   NP_071953 93
M.musculus Mthfd1 108156 Gene Info NP_620084 93
C.elegans K07E3.4 181064   NP_509361 71
A.thaliana THFS 841470   NP_564571 68
A.gambiae AgaP_AGAP002830 1273131   XP_312083 63
N.crassa NCU03877 3872688   XP_956550 62
D.melanogaster pug 41279   NP_731489 61
S.pombe SPBC839.16 2541217   NP_595256 60
S.cerevisiae ADE3 853118   NP_011720 59

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)