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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. DHFR, dihydrofolate reductase
Sequence ID:NM_000791
RefSeqGene ID:NG_023304
Entrez Gene ID:1719
Ensembl ID:ENSG00000228716

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
MEGALOBLASTIC ANEMIA DUE TO DIHYDROFOLATE REDUCTASE DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q11.2-q13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 79924041 - 79950377

NM_000791 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
1629557992204479924983
295630717992969579929810
307231987993370179933827
319933047994520779945312
330533547994982679949875
335539327995022279950799

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3352539Full LengthBC000192dihydrofolate reductase
3354190Full LengthBC003584dihydrofolate reductase
4645596Full LengthBC071996dihydrofolate reductase
6714220Full LengthBC070280dihydrofolate reductase
3891285IncompleteBC009634dihydrofolate reductase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000782  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000791 NP_000782 P00374 EC 1.5.1.3 DHFR_1
NM_002439 NP_002430 P20585   MutS_V
MutS_I
MutS_II
MutS_III

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
J00140 AAA58485 P00374 EC 1.5.1.3
U61981 AAB06045 P20585  
J04810 AAB47281 P20585  
BC000192 AAH00192 P00374 EC 1.5.1.3
BC003584 AAH03584 P00374 EC 1.5.1.3
BC011817 AAH11817 P20585  
BC070280 AAH70280 P00374 EC 1.5.1.3
BC071996 AAH71996 P00374 EC 1.5.1.3
BC130434 AAI30435 A1L480  
BC130436 AAI30437 P20585  
DQ892816 ABM83742    
DQ896062 ABM87061    
EU145592 ABX57718 B0YJ76  
AK289856 BAF82545 A8K1E1  
AK312642 BAG35526 B0YJ76  
AK293146 BAG56693 B4DDD2  
AK297302 BAG59770 B4DM58  
V00507 CAA23765 P00374 EC 1.5.1.3

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens DHFR NP_000782 M.musculus Dhfr 13361 Gene Info NP_034179 90
R.norvegicus Dhfr 24312   NP_569084 90
D.melanogaster Dhfr 42003   NP_001036720 49
A.gambiae AgaP_AGAP010278 1279701   XP_319471 43
C.elegans dhfr-1 172681   NP_492364 37
S.cerevisiae DFR1 854411   NP_014879 36

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta