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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TGFB1, transforming growth factor, beta 1
Sequence ID:NM_000660
RefSeqGene ID:NG_013364
Entrez Gene ID:7040
Ensembl ID:ENSG00000105329

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebrum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
CAMURATI-ENGELMANN DISEASE 
CYSTIC FIBROSISCFTR
CFTR
CFTR

Cytogenetic Location (from UniGene)

Cytogenetic Location:19q13.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 41836819 - 41859327

NM_000660 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
193214183681241837114
3224754183803241838185
4766234184778741847934
6247014184807441848151
7028194185065141850768
8209804185419941854359
98122174185859441859830

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3351664Full LengthBC000125transforming growth factor, beta 1
3356605Full LengthBC001180transforming growth factor, beta 1
4399762Full LengthBC022242transforming growth factor, beta 1

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000651  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000660 NP_000651 P01137 TGF_beta
TGFb_propeptide

Related Sequences

 
mRNAGenPeptSwissProt
M38449 AAA36735 P01137
BC000125 AAH00125 P01137
BC001180 AAH01180 P01137
BC022242 AAH22242 P01137
BT007245 AAP35909 P01137
AY820829 AAV71148 Q5PY19
EU832225 ACE86795  
EU832132 ACE87482  
AK291907 BAF84596 P01137
X02812 CAA26580 P01137

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TGFB1 NP_000651 R.norvegicus Tgfb1 59086   NP_067589 90
M.musculus Tgfb1 21803 Gene Info NP_035707 90

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta