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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PMS2, PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
Sequence ID:NM_000535
NR_003085
RefSeqGene ID:NG_008466
Entrez Gene ID:5395
Ensembl ID:ENSG00000122512

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
COLORECTAL CANCER,HEREDITARY NONPOLYPOSIS, TYPE 4 
MISMATCH REPAIR CANCER SYNDROMEAPC
APC
MLH1
MSH2
MSH6

Cytogenetic Location (from UniGene)

Cytogenetic Location:7p22.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:7: 6017304 - 6048650

 Exon Info From UCSC:
NM_000535

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
7939766Full LengthBC093921PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
4273792IncompleteBC008400PMS2 postmeiotic segregation increased 2 (S. cerevisiae)
4419131IncompleteBC031832PMS2 postmeiotic segregation increased 2 (S. cerevisiae)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000526  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000535 NP_000526 P54278 DNA_mis_repair
HATPase_c

Related Sequences

 
mRNAGenPeptSwissProt
U14658 AAA50390 P54278
BC093921 AAH93921 P54278
AB103082 BAD89425 P54278
AB103083 BAD89426 P54278
AB103085 BAD89428 P54278
AB103086 BAD89429 Q5FBW8
AK312390 BAG35307 P54278
AK294661 BAG57831 B4DGM0
BX537558 CAD97782 Q7Z3Q2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PMS2 NP_000526 M.musculus Pms2 18861 Gene Info NP_032912 79
A.gambiae AgaP_AGAP007126 1269980   XP_308635 45
D.melanogaster Pms2 36705   NP_477023 45
N.crassa NCU08020 3878856   XP_962690 43
A.thaliana PMS1 827997   NP_567236 41
S.cerevisiae PMS1 855642   NP_014317 39
S.pombe pms1 2542582   NP_594417 38
C.elegans pms-2 179587   NP_505933 36

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)