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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HMGCR, 3-hydroxy-3-methylglutaryl-CoA reductase
Sequence ID:NM_000859
NM_001130996
RefSeqGene ID:NG_011449
Entrez Gene ID:3156
Ensembl ID:ENSG00000113161

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssemblies

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q13.3-q14Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 74633061 - 74656326

 Exon Info From UCSC:
NM_000859
NM_001130996

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5212903Full LengthBC0336923-hydroxy-3-methylglutaryl-Coenzyme A reductase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000850  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000859 NP_000850 P04035 EC 1.1.1.34 HMG-CoA_red
NM_001130996 NP_001124468      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M11058 AAA52679 P04035 EC 1.1.1.34
BC033692 AAH33692 P04035 EC 1.1.1.34
DQ890855 ABM81781    
DQ894009 ABM84935    
AK292892 BAF85581 A8KA27  
AK312437 BAG35346 B2R649  
AK299655 BAG61573 B4DSB1  
AK296499 BAH12375 B7Z3Y9  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HMGCR NP_000850 M.musculus Hmgcr 15357 Gene Info NP_032281 94
R.norvegicus Hmgcr 25675   NP_037266 93
N.crassa NCU00712 3880697   XP_964546 61
A.thaliana HMG1 843982   NP_177775 57
S.pombe hmg1 2538999   NP_588235 56
D.melanogaster Hmgcr 42803   NP_001163703 51
A.gambiae AgaP_AGAP002288 1269263   XP_307890 50
C.elegans F08F8.2 176047   NP_498626 48
S.cerevisiae HMG1 854900   NP_013636 43
S.cerevisiae HMG2 851171   NP_013555 41

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)