Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HEXA, hexosaminidase A (alpha polypeptide)
Sequence ID:NM_000520
RefSeqGene ID:NG_009017
Entrez Gene ID:3073
Ensembl ID:ENSG00000213614

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
GM2-GANGLIOSIDOSIS, SEVERAL FORMS 

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q24.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 72636229 - 72668327

 Exon Info From UCSC:
NM_000520

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3353424Full LengthBC018927hexosaminidase A (alpha polypeptide)
5459166Full LengthBC084537hexosaminidase A (alpha polypeptide)
2989846IncompleteBC001138hexosaminidase A (alpha polypeptide)
3626334IncompleteBC021030hexosaminidase A (alpha polypeptide)
4823589IncompleteBC034424hexosaminidase A (alpha polypeptide)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000511  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000520 NP_000511 P06865 EC 3.2.1.52 Glyco_hydro_20
Glyco_hydro_20b

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M13520 AAA51827 P06865 EC 3.2.1.52
S76980 AAB33748    
S61298 AAD13927 Q16017  
BC001138 AAH01138 Q9BVJ8  
BC018927 AAH18927 P06865 EC 3.2.1.52
BC021030 AAH21030 Q6PJ76  
BC084537 AAH84537 P06865 EC 3.2.1.52
DQ892696 ABM83622    
EU176728 ABW03529    
AK222502 BAD96222 P06865 EC 3.2.1.52
AK296528 BAG59159 B4DKE7  
AK297678 BAG60039 B4DMX7  
AK301000 BAG62619 B4DVA7  
AK301138 BAG62730 B4DVL8  
CR627386 CAH10482 P06865 EC 3.2.1.52

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HEXA NP_000511 M.musculus Hexa 15211 Gene Info NP_034551 84
R.norvegicus Hexa 300757   NP_001004443 83
A.thaliana HEXO3 842871   NP_176737 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)