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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. POLR2B, polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
Sequence ID:NM_000938
Entrez Gene ID:5431
Ensembl ID:ENSG00000047315

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:4q12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:4: 57883347 - 57897323

 Exon Info From UCSC:
NM_000938

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3346389Full LengthBC023503polymerase (RNA) II (DNA directed) polypeptide B, 140kDa

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000929  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000938 NP_000929 P30876 EC 2.7.7.6 RNA_pol_Rpb2_6
RNA_pol_Rpb2_7
RNA_pol_Rpb2_2
RNA_pol_Rpb2_1
RNA_pol_Rpb2_3
RNA_pol_Rpb2_4
RNA_pol_Rpb2_5

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF055028 AAC09367 P30876 EC 2.7.7.6
BC023503 AAH23503 P30876 EC 2.7.7.6
AK289823 BAF82512 P30876 EC 2.7.7.6
AK294901 BAG57990 B4DH29  
AK295132 BAG58155 B4DHJ3  
AK299090 BAG61152 B4DR40  
X63563 CAA45124 P30876 EC 2.7.7.6

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens POLR2B NP_000929 M.musculus Polr2b 231329 Gene Info NP_722493 100
R.norvegicus Polr2b 289561   NP_001099472 100
A.gambiae AgaP_AGAP003648 1274316   XP_313416 87
D.melanogaster RpII140 41721   NP_476706 86
C.elegans rpb-2 175668   NP_498047 79
A.thaliana NRPB2 828259   NP_193902 68
S.pombe rpb2 2541446   NP_593101 64
N.crassa NCU05120 3873253   XP_957106 63
S.cerevisiae RPB2 854322   NP_014794 61
P.falciparum PFB0715w 812744   XP_001349662 55

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)