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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HMGCS2, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
Sequence ID:NM_001166107
NM_005518
RefSeqGene ID:NG_013348
Entrez Gene ID:3158
Ensembl ID:ENSG00000134240

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
HMG-COA SYNTHASE-2 DEFICIENCY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p13-p12Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 120291259 - 120311524

 Exon Info From UCSC:
NM_001166107
NM_005518

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5744956Full LengthBC0442173-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005509  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001166107 NP_001159579      
NM_005518 NP_005509 P54868 EC 2.3.3.10 HMG_CoA_synt_N
HMG_CoA_synt_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U12788 AAA92673 P54868 EC 2.3.3.10
U12789 AAA92674 P54868 EC 2.3.3.10
BC044217 AAH44217 P54868 EC 2.3.3.10
GU433940 ADD21696 D3Y5K6  
AK301594 BAH13520 B7Z784  
AK302276 BAH13664 B7Z7M8  
AK303777 BAH14049 P54868 EC 2.3.3.10
X83618 CAA58593 P54868 EC 2.3.3.10
CR456850 CAG33131 Q6IBF4  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HMGCS2 NP_005509 M.musculus Hmgcs2 15360 Gene Info NP_032282 89
R.norvegicus Hmgcs2 24450   NP_775117 89

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)