Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. UBE3A, Ubiquitin protein ligase E3A
Sequence ID:NM_000462
NM_130839
NM_130838
RefSeqGene ID:NG_002690
Entrez Gene ID:7337
Ensembl ID:ENSG00000114062

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
ANGELMAN SYNDROMECDKL5
MECP2
MECP2

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q11.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 25584283 - 25653795

 Exon Info From UCSC:
NM_000462
NM_130839
NM_130838

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3160225Full LengthBC002582ubiquitin protein ligase E3A
3353595Full LengthBC009271ubiquitin protein ligase E3A

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_570853  NP_570854  NP_000453  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000462 NP_000453 Q05086 HECT
NM_130838 NP_570853 Q9H2G0 HECT
NM_130839 NP_570854   HECT

Related Sequences

 
mRNAGenPeptSwissProt
L07557 AAA35542 Q05086
U84404 AAB49301 Q9H2G0
Q05086
AF273050 AAG34910 Q9H2G0
BC002582 AAH02582 Q9BUI6
BC009271 AAH09271 Q96GR7
JF432815 ADZ16032  
AB194232 BAD69553 Q5W7F8
AB194232 BAD69554 Q5W7F7
AK291405 BAF84094 Q9H2G0
AK292514 BAF85203 Q05086
X98031 CAA66654 Q05086
X98032 CAA66655 Q05086
X98033 CAA66656 Q05086

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens UBE3A NP_570854 R.norvegicus Ube3a 361585   XP_341868 97
M.musculus Ube3a 22215 Gene Info NP_035798 96
A.gambiae AgaP_AGAP012366 3291570   XP_551819 52
D.melanogaster Ube3a 39266   NP_648452 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)