Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. MSH2, mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
Sequence ID:NM_000251
NM_001258281
RefSeqGene ID:NG_007110
Entrez Gene ID:4436
Ensembl ID:ENSG00000095002

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pituitary gland, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 1 
GLIOBLASTOMABRCA2
DMBT1
ERBB2
LGI1
PPARG
PTEN
WDR11
MISMATCH REPAIR CANCER SYNDROMEAPC
APC
MLH1
MSH6
PMS2
MUIR-TORRE SYNDROMEMLH1
NEUROFIBROMATOSIS, TYPE 1NF1

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 47630268 - 47739716


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4110354Full LengthBC021566mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
2989085IncompleteBC001122mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000242  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000251 NP_000242 P43246 MutS_V
MutS_I
MutS_II
MutS_IV
MutS_III
NM_001258281 NP_001245210    

Related Sequences

 
mRNAGenPeptSwissProt
U03911 AAA18643 P43246
U04045 AAA61870 P43246
L47581 AAA76858 P43246
L47583 AAB59564 P43246
L47582 AAB59565 P43246
L47574 AAB59566  
L47575 AAB59567  
L47576 AAB59568  
L47577 AAB59569  
L47578 AAB59570  
L47579 AAB59571  
L47580 AAB59572  
BC021566 AAH21566 P43246
DQ648894 ABG49489 Q0ZAJ2
DQ648895 ABG49490 Q0ZAJ1
DQ648896 ABG49491 Q0ZAJ0
DQ648897 ABG49492 Q0ZAI9
DQ892558 ABM83484  
DQ895772 ABM86698  
AK222860 BAD96580 Q53GS1
AK223284 BAD97004 Q53FK0
AK296831 BAG59401 B4DL39
AK297763 BAG60111 B4DN49
AK299667 BAG61581 B4DSB9
AK304496 BAG65304 B4E2Z2

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens MSH2 NP_000242 M.musculus Msh2 17685 Gene Info NP_032654 93
R.norvegicus Msh2 81709   NP_112320 92
N.crassa NCU02230 3875790   XP_959643 49
D.melanogaster spel1 34842   NP_523565 46
A.gambiae AgaP_AGAP010282 1279706   XP_319476 44
A.thaliana MSH2 821383   NP_566804 44
S.cerevisiae MSH2 854063   NP_014551 44
S.pombe msh2 2540695   NP_595967 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)