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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. LSS, lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
Sequence ID:NM_001001438
RefSeqGene ID:NG_011510
Entrez Gene ID:4047
Ensembl ID:ENSG00000160285

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:21q22.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:21: 47609042 - 47648651

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5547173Full LengthBC035638lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_001001438  NP_002331  

Protein Infomation

NM_001001438 NP_001001438 P48449 EC Prenyltrans
NM_001145436 NP_001138908      
NM_001145437 NP_001138909      
NM_002340 NP_002331 P48449 EC Prenyltrans

Related Sequences

S81221 AAB36220 P48449 EC
BC035638 AAH35638 P48449 EC
DQ891234 ABM82160    
DQ894418 ABM85344    
D63807 BAA09875 P48449 EC
AK092334 BAC03865 Q8NAP6  
AK096769 BAC04859 Q8N8I2  
AK098352 BAC05289 Q8N7J1  
AK128839 BAC87638 Q6ZQP6  
AK312489 BAG35391 B2R694  
AK296313 BAG59011 B4DJZ9  
X87809 CAA61078 P48449 EC

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens LSS NP_001001438 M.musculus Lss 16987 Gene Info NP_666118 86
R.norvegicus Lss 81681   NP_112311 85
A.thaliana CAS1 815275   NP_178722 50
N.crassa NCU01119 3877205   XP_961026 43
S.cerevisiae ERG7 856470   NP_011939 43
S.pombe erg7 2542882   NP_593702 43

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)