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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. LMNA, lamin A/C
Sequence ID:NM_001257374
NM_005572
NM_170707
NM_170708
NR_047544
NR_047545
RefSeqGene ID:NG_008692
Entrez Gene ID:4000
Ensembl ID:ENSG00000160789

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, adrenal medulla, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
?CARDIOMYOPATHY, DILATEDMYBPC3
CHARCOT-MARIE-TOOTH DISEASE,TYPE 2B1 
EMERY-DREIFUSS MUSCULAR DYSTROPHY 2, AD 
HEART-HAND SYNDROME, SLOVENIAN TYPE 
HUTCHINSON-GILFORD PROGERIAZMPSTE24
ZMPSTE24
LIPODYSTROPHY, FAMILIAL PARTIAL, 2PPARG
MALOUF SYNDROME 
MANDIBULOACRAL DYSPLASIA 
MUSCULAR DYSTROPHY, CONGENITAL 
MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 1B 
RESTRICTIVE DERMOPATHY, LETHALZMPSTE24
ZMPSTE24
WERNER SYNDROMEWRN

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 156105877 - 156108962

 Exon Info From UCSC:
NM_005572
NM_170707
NM_170708

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2822703Full LengthBC000511lamin A/C
2958052Full LengthBC003162lamin A/C
3623265Full LengthBC033088lamin A/C
4863480Full LengthBC014507lamin A/C

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_733821  NP_005563  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001257374 NP_001244303    
NM_005572 NP_005563   Filament
IF_tail
NM_170707 NP_733821 P02545 Filament
IF_tail
NM_170708 NP_733822    

Related Sequences

 
mRNAGenPeptSwissProt
M13452 AAA36160 P02545
M13451 AAA36164 P02545
BC000511 AAH00511 P02545
BC003162 AAH03162 P02545
BC014507 AAH14507 P02545
BC033088 AAH33088 Q8N519
AF381029 AAK59326 P02545
AY357727 AAR29466 Q6UYC3
AY847595 AAW32538 Q5I6Y6
AY847596 AAW32539 Q5I6Y5
AY847597 AAW32540 Q5I6Y4
AY528714 ABB04050 Q3BDU5
EU831836 ACE86595  
EU832261 ACE86831  
EU831758 ACE87276  
EU832167 ACE87517  
AK294217 BAG57524 B4DFR3
AK295390 BAG58344 B4DI32
X03444 CAA27173 P02545
X03445 CAA27174 P02545

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens LMNA NP_733821 M.musculus Lmna 16905 Gene Info NP_001002011 97
R.norvegicus Lmna 60374   NP_001002016 85
A.gambiae AgaP_AGAP008015 1277933   XP_317447 38

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta