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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TCF7L2, Transcription factor 7-like 2 (T-cell specific, HMG-box)
Sequence ID:NM_001198525
NM_001198528
NM_001146274
NM_001146283
NM_001198527
NM_030756
NM_001146285
NM_001198526
NM_001198531
NM_001198529
NM_001146284
NM_001146286
NM_001198530
RefSeqGene ID:NG_012631
Entrez Gene ID:6934
Ensembl ID:ENSG00000148737

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
DIABETES MELLITUS, NON-INSULIN-DEPENDENTABCC8
AKT2
CDKAL1
ENPP1
GCGR
GCK
GPD2
HMGA1
HMGA1
HNF1A
HNF1B
HNF4A
IGF2BP2
IL6
IRS1
IRS2
KCNJ11
LIPC
MAPK8IP1
MTNR1B
NEUROD1
NEUROD1
NEUROD1
PAX4
PDX1
PPARG
PTPN1
RETN
SLC2A4
SLC30A8
VEGFA
WFS1
WFS1

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q25.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 114918451 - 114925357

 Exon Info From UCSC:
NM_001146274
NM_001146283
NM_030756
NM_001146285
NM_001146284
NM_001146286

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5533185Full LengthBC032656transcription factor 7-like 2 (T-cell specific, HMG-box)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_110383  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001146274 NP_001139746    
NM_001146283 NP_001139755    
NM_001146284 NP_001139756    
NM_001146285 NP_001139757    
NM_001146286 NP_001139758    
NM_001198525 NP_001185454    
NM_001198526 NP_001185455    
NM_001198527 NP_001185456    
NM_001198528 NP_001185457    
NM_001198529 NP_001185458    
NM_001198530 NP_001185459    
NM_001198531 NP_001185460    
NM_030756 NP_110383   HMG_box
CTNNB1_binding

Related Sequences

 
mRNAGenPeptSwissProt
BC032656 AAH32656 Q9NQB0
FJ010164 ACI28522 C6ZRJ5
FJ010165 ACI28523 C6ZRJ6
FJ010166 ACI28524 C6ZRJ7
FJ010167 ACI28525 C6ZRJ8
FJ010168 ACI28526 C6ZRJ9
FJ010169 ACI28527 C6ZRK0
FJ010170 ACI28528 C6ZRK1
FJ010171 ACI28529 C6ZRK2
FJ010172 ACI28530 B4DRJ8
FJ010173 ACI28531 C6ZRK4
FJ010174 ACI28532 C6ZRK5
HM352838 ADK35174 E2GH13
HM352839 ADK35175 E2GH14
HM352840 ADK35176 E2GH15
HM352841 ADK35177 E2GH16
HM352842 ADK35178 B4DRJ8
HM352843 ADK35179 E2GH18
HM352844 ADK35180 E2GH19
HM352846 ADK35181 B9X074
HM352847 ADK35182 C6ZRJ8
HM352848 ADK35183 E2GH23
HM352849 ADK35184 E2GH24
HM352850 ADK35185 E2GH25
HM352851 ADK35186 E2GH26
HM352845 ADK35187 E2GH20
AB034691 BAA86225 Q9NQB0
AK074705 BAG51988 B3KQC6
AK296305 BAG59004 B4DJZ2
AK299295 BAG61310 B4DRJ8
AK301483 BAG62997 B4DWD5
AK303684 BAG64677 B4E165
AB451266 BAG70080 B5BU30
AK316111 BAH14482 B7Z9Z6
AB440195 BAH24004 B9X074
Y11306 CAA72166 Q9NQB0
CR536574 CAG38811 Q6FHW4

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TCF7L2 NP_001185455 R.norvegicus Tcf7l2 679869   XP_001054844 98
M.musculus Tcf7l2 21416 Gene Info NP_001136394 97
A.gambiae AgaP_AGAP012389 1280326   XP_320170 54
D.melanogaster pan 43769   NP_001014685 46

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)