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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. IDH1, isocitrate dehydrogenase 1 (NADP+), soluble
Sequence ID:NM_005896
RefSeqGene ID:NG_023319
Entrez Gene ID:3417
Ensembl ID:ENSG00000138413

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:2q33.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 209100952 - 209119806

NM_005896 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
12951209100953209101892
9521114209103794209103956
11151255209104586209104726
12561407209106717209106868
14081585209108150209108327
15861691209110042209110147
16921983209113092209113383
19842121209116153209116290
21222195209118609209118682
21962339209119662209119805

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3880331Full LengthBC012846isocitrate dehydrogenase 1 (NADP+), soluble
30528912Full LengthBC093020isocitrate dehydrogenase 1 (NADP+), soluble

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005887  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_005896 NP_005887 O75874
Q6FHQ6
EC 1.1.1.42 Iso_dh

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U62389 AAB17375 O75874 EC 1.1.1.42
AF020038 AAD02918 O75874 EC 1.1.1.42
AF113917 AAD29284 O75874
Q6FHQ6
EC 1.1.1.42
BC012846 AAH12846 O75874
Q6FHQ6
EC 1.1.1.42
BC093020 AAH93020 Q567U4  
DQ403082 ABD77215 Q0QER2  
DQ891435 ABM82361    
EU176595 ABW03396    
AK312242 BAG35175 B2R5M8  
AK302105 BAG63486 B4DXS4  
AL136702 CAB66637 O75874 EC 1.1.1.42
BX537411 CAD97653 O75874 EC 1.1.1.42
CR533522 CAG38553 Q6FIA4  
CR536499 CAG38738 Q6FI37  
CR541695 CAG46496 O75874
Q6FHQ6
EC 1.1.1.42
AM392584 CAL37462    
AM392612 CAL37490    
AM393191 CAL38069    

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens IDH1 NP_005887 R.norvegicus Idh1 24479   NP_113698 96
M.musculus Idh1 15926 Gene Info NP_001104790 96
A.gambiae AgaP_AGAP006660 1277248   XP_001688948 76
C.elegans F59B8.2 177775   NP_501665 76
D.melanogaster Idh 44291   NP_652044 73
A.thaliana cICDH 842905   NP_176768 68
S.cerevisiae IDP2 850871   NP_013275 61

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)