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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. FH, fumarate hydratase
Sequence ID:NM_000143
RefSeqGene ID:NG_012338
Entrez Gene ID:2271
Ensembl ID:ENSG00000091483

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
FUMARASE DEFICIENCY 
LEIOMYOMATOSIS AND RENAL CELL CANCER 

Cytogenetic Location (from UniGene)

Cytogenetic Location:1q42.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 241661127 - 241683061

NM_000143 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
11424241660856241661269
425578241663736241663889
579706241665742241665869
707910241667341241667544
9111076241669302241669467
10771259241671902241672084
12601436241675266241675442
14371547241676902241677012
15481682241680481241680615
16831877241682890241683084

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3502012Full LengthBC003108fumarate hydratase
3606118Full LengthBC017444fumarate hydratase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000134  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000143 NP_000134 P07954 EC 4.2.1.2 Lyase_1

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M15502 AAA52483 P07954 EC 4.2.1.2
U59309 AAB66354 P07954 EC 4.2.1.2
U48857 AAD00071 P07954 EC 4.2.1.2
BC003108 AAH03108 P07954 EC 4.2.1.2
BC017444 AAH17444 P07954 EC 4.2.1.2
BT009839 AAP88841 P07954 EC 4.2.1.2
EU176358 ABW03809    
AK312415 BAG35325 B1ANK7  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens FH NP_000134 M.musculus Fh1 14194 Gene Info NP_034339 93
R.norvegicus Fh 24368   NP_058701 93
A.gambiae AgaP_AGAP001884 1281238   XP_321179 78
D.melanogaster l(1)G0255 31605   NP_572339 77
C.elegans fum-1 176059   NP_498642 74
A.thaliana FUM1 819364   NP_001078075 70
A.thaliana FUM2 835168   NP_199908 70
S.pombe fum1 2539345   NP_588397 69
S.cerevisiae FUM1 855866   NP_015061 67
N.crassa NCU10008 3875601   XP_959454 67

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)