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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. TOP3A, topoisomerase (DNA) III alpha
Sequence ID:NM_004618
Entrez Gene ID:7156
Ensembl ID:ENSG00000177302

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:17p12-p11.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 18177234 - 18177778

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
6044661Full LengthBC051748topoisomerase (DNA) III alpha

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004609  

Protein Infomation

NM_004618 NP_004609 Q13472 EC Topoisom_bac

Related Sequences

U43431 AAB03694 Q13472 EC
U43431 AAB03695 Q13472 EC
BC051748 AAH51748 Q13472 EC
AK290513 BAF83202 A8K398  
AK292926 BAF85615 Q13472 EC
AK126869 BAG54385 A8K398  
AK296437 BAG59092 B4DK80  
AK299764 BAG61652 B4DSJ0  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens TOP3A NP_004609 M.musculus Top3a 21975 Gene Info NP_033436 87
R.norvegicus Top3a 303194   XP_002742497 85
D.melanogaster Top3alpha 35236   NP_523602 55
C.elegans top-3 176631   NP_499558 53
A.gambiae AgaP_AGAP010028 1279455   XP_319175 51
N.crassa NCU00081 3872529   XP_956391 48
A.thaliana TOP3A 836513   NP_201197 47
S.cerevisiae TOP3 850935   NP_013335 45
S.pombe top3 2539881   NP_596761 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)