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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PLK1, polo-like kinase 1
Sequence ID:NM_005030
Entrez Gene ID:5347
Ensembl ID:ENSG00000166851

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, placenta, pooled tissue, prostate, salivary gland, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:16p12.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:16: 23690250 - 23701688

NM_005030 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
14612369020023690660
4626302369140423691572
6317752369223423692378
7768692369338423693477
87010892369519023695409
109012452369878923698944
124613232369998823700065
132414782370055823700712
147916612370081423700996
166221692370118023701687

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2822226Full LengthBC002369polo-like kinase 1 (Drosophila)
2823623Full LengthBC003002polo-like kinase 1 (Drosophila)
3854860Full LengthBC014846polo-like kinase 1 (Drosophila)
4634174IncompleteBC014135polo-like kinase 1 (Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_005021  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_005030 NP_005021 P53350 EC 2.7.11.21 Pkinase
POLO_box

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
L19559 AAA36659 P53350 EC 2.7.11.21
U01038 AAA56634 P53350 EC 2.7.11.21
BC002369 AAH02369 P53350 EC 2.7.11.21
BC003002 AAH03002 P53350 EC 2.7.11.21
BC014846 AAH14846 P53350 EC 2.7.11.21
DQ891045 ABM81971    
DQ894224 ABM85150    
AB209179 BAD92416 Q59GD0  
AB084459 BAD93352 Q58A51  
AK313227 BAG36038 B2R841  
AK303263 BAG64345 B4E083  
X73458 CAA51837 P53350 EC 2.7.11.21
X75932 CAA53536 P53350 EC 2.7.11.21

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PLK1 NP_005021 M.musculus Plk1 18817 Gene Info NP_035251 95
R.norvegicus Plk1 25515   NP_058796 94
C.elegans plk-1 176143   NP_001021174 55
D.melanogaster polo 40232   NP_524179 55
C.elegans plk-2 171838   NP_491036 54
A.gambiae AgaP_AGAP004239 1274084   XP_313155 53
S.pombe plo1 2541957   NP_593647 45
S.cerevisiae CDC5 855013   NP_013714 40

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta