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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. NPM1, nucleophosmin (nucleolar phosphoprotein B23, numatrin)
Sequence ID:NM_001037738
NM_002520
NM_199185
RefSeqGene ID:NG_016018
Entrez Gene ID:4869
Ensembl ID:ENSG00000181163

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
LEUKEMIA, ACUTE MYELOGENOUSARHGEF12
CBFB
CEBPA
CHIC2
ETV6
FLT3
GATA2
GMPS
JAK2
KIT
LPP
MLF1
MLLT10
NSD1
NUP214
PICALM
RUNX1
RUNX1
SH3GL1
TERT
WHSC1L1

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q35.1Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 170814952 - 170833489

 Exon Info From UCSC:
NM_001037738
NM_002520
NM_199185

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2821577Full LengthBC002398nucleophosmin (nucleolar phosphoprotein B23, numatrin)
3511037Full LengthBC014349nucleophosmin (nucleolar phosphoprotein B23, numatrin)
3877633Full LengthBC009623nucleophosmin (nucleolar phosphoprotein B23, numatrin)
3930893Full LengthBC021668nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4068167Full LengthBC016716nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4081364Full LengthBC016768nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4097025Full LengthBC012566nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4106023Full LengthBC021983nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4106286Full LengthBC016824nucleophosmin (nucleolar phosphoprotein B23, numatrin)
4276604Full LengthBC008495nucleophosmin (nucleolar phosphoprotein B23, numatrin)
5575414Full LengthBC050628nucleophosmin (nucleolar phosphoprotein B23, numatrin)
6736004Full LengthBC107754nucleophosmin (nucleolar phosphoprotein B23, numatrin)
3932340IncompleteBC003670nucleophosmin (nucleolar phosphoprotein B23, numatrin)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_954654  NP_002511  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001037738 NP_001032827    
NM_002520 NP_002511 P06748 Nucleoplasmin
NM_199185 NP_954654   Nucleoplasmin

Related Sequences

 
mRNAGenPeptSwissProt
M23613 AAA36380 P06748
M26697 AAA36385 P06748
J02590 AAA36473 P06748
M31004 AAA36474 P06748
M28699 AAA58386 P06748
BC002398 AAH02398 P06748
BC003670 AAH03670 Q9BTI9
BC008495 AAH08495 P06748
BC009623 AAH09623 P06748
BC012566 AAH12566 P06748
BC014349 AAH14349 P06748
BC016716 AAH16716 P06748
BC016768 AAH16768 P06748
BC016824 AAH16824 P06748
BC021668 AAH21668 P06748
BC021983 AAH21983 P06748
BC050628 AAH50628 P06748
BC107754 AAI07755 P06748
BT007011 AAP35657 P06748
AY347529 AAQ24860 P06748
AY740634 AAW67752 P06748
AY740635 AAW67753 P06748
AY740636 AAW67754 P06748
AY740637 AAW67755 P06748
AY740638 AAW67756 P06748
AY740639 AAW67757 P06748
AY740640 AAW67758 P06748
DQ303464 ABC40399 P06748
DQ892032 ABM82958  
DQ895223 ABM86149  
EF429251 ABP97432 A4ZU86
D28343 BAA05709  
AK000472 BAA91188 Q9NX34
AB042278 BAB40600 P06748
AK290652 BAF83341 P06748
AB451236 BAG70050 P06748
AB451361 BAG70175 P06748
X16934 CAA34809 P06748

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens NPM1 NP_002511 M.musculus Npm1 18148 Gene Info NP_032748 96
R.norvegicus Npm1 25498   NP_037124 96

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)