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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. NKX2-5, NK2 homeobox 5
Sequence ID:NM_001166175
NM_001166176
NM_004387
RefSeqGene ID:NG_013340
Entrez Gene ID:1482
Ensembl ID:ENSG00000183072

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ATRIAL SEPTAL DEFECT 7, WITH OR WITHOUT AV CONDUCTION DEFECTS 
CONOTRUNCAL ANOMALY FACE SYNDROMECFC1
GATA6
GATA6
GDF1
NKX2-6
TBX1
HYPOPLASTIC LEFT HEART SYNDROME 2 
HYPOTHYROIDISM, CONGENITAL NONGOITROUS, 5 
TETRALOGY OF FALLOTGATA6
GATA6
GDF1
JAG1
JAG1
ZFPM2
VENTRICULAR SEPTAL DEFECT 3 

Cytogenetic Location (from UniGene)

Cytogenetic Location:5q34Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:5: 172659571 - 172662086

 Exon Info From UCSC:
NM_001166175
NM_001166176
NM_004387

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5225103Full LengthBC025711NK2 transcription factor related, locus 5 (Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004378  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001166175 NP_001159647    
NM_001166176 NP_001159648    
NM_004387 NP_004378 P52952 Homeobox

Related Sequences

 
mRNAGenPeptSwissProt
U34962 AAC50470 P52952
BC025711 AAH25711 P52952
DQ893313 ABM84239  
DQ894104 ABM85030  
DQ896627 ABM87626  
AB021133 BAA35181 P52952
AK290615 BAF83304 P52952
AK297844 BAG60178 P52952

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens NKX2-5 NP_004378 M.musculus Nkx2-5 18091 Gene Info NP_032726 89
R.norvegicus Nkx2-5 114109   NP_446103 87

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta