Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PTPN22, protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
Sequence ID:NM_001193431
NM_012411
NM_015967
RefSeqGene ID:NG_011432
Entrez Gene ID:26191
Ensembl ID:ENSG00000134242

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
?SYSTEMIC LUPUS ERYTHEMATOSUS, OR PROTECTION AGAINSTBANK1
C4A
C4A
DNASE1
DNASE1
FASLG
FCGR2B
FCGR3A
ITGAX
PDCD1
STAT4
STAT4
TREX1
TREX1
TREX1
DIABETES MELLITUS, INSULIN-DEPENDENTFOXP3
HLA-DQB1
HLA-DQB1
HNF1A
ITPR3
OAS1
SH2B3
RHEUMATOID ARTHRITISCD244
CIITA
HLA-DRB1
HLA-DRB1
HLA-DRB1
IL10
NFKBIL1
PADI4
RUNX1
RUNX1
SLC22A4
STAT4
STAT4

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 114356929 - 114414286

 Exon Info From UCSC:
NM_001193431
NM_012411
NM_015967

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5497108Full LengthBC071670protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_057051  NP_036543  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001193431 NP_001180360      
NM_012411 NP_036543     Y_phosphatase
NM_015967 NP_057051 Q9Y2R2 EC 3.1.3.48 Y_phosphatase

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U69700 AAB09079 Q93095  
AF001846 AAD00904 Q9Y2R2 EC 3.1.3.48
AF077031 AAD27764 Q9Y2R2 EC 3.1.3.48
AF150732 AAF67472 Q9P0U2  
BC017785 AAH17785 Q9Y2R2 EC 3.1.3.48
BC071670 AAH71670 Q9Y2R2 EC 3.1.3.48
GU479452 ADD59979 Q9Y2R2 EC 3.1.3.48
JN084012 AEL79472 G3K0T4  
AK303124 BAG64230 B4DZW8  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PTPN22 NP_057051 M.musculus Ptpn22 19260 Gene Info NP_033005 72
R.norvegicus Ptpn22 295338   NP_001099930 70

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)