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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. C4A, complement component 4A (Rodgers blood group)
Sequence ID:XM_003960046
XM_003960047
NM_001252204
NM_007293
RefSeqGene ID:NG_011638
Entrez Gene ID:720
Ensembl ID:ENSG00000244731

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
?SYSTEMIC LUPUS ERYTHEMATOSUS, OR PROTECTION AGAINSTBANK1
DNASE1
DNASE1
FASLG
FCGR2B
FCGR3A
ITGAX
PDCD1
PTPN22
STAT4
STAT4
TREX1
TREX1
TREX1
C4A DEFICIENCY 
[BLOOD GROUP, RODGERS] 

Cytogenetic Location (from UniGene)

Cytogenetic Location:6p21.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:6: 31949844 - 31970440


Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5289068Full LengthBC063289complement component 4A (Rodgers blood group)
9053073Full LengthBC144546complement component 4A (Rodgers blood group)
9054440Full LengthBC171786complement component 4A (Rodgers blood group)
9056777Full LengthBC146849complement component 4A (Rodgers blood group)
40147083Full LengthBC151204complement component 4A (Rodgers blood group)
40148477Full LengthBC146673complement component 4A (Rodgers blood group)
4186970IncompleteBC012372complement component 4A (Rodgers blood group)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_009224  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001002029 NP_001002029 Q6U2E9 A2M
NTR
ANATO
A2M_N
A2M_recep
A2M_comp
A2M_N_2
NM_001242823 NP_001229752    
NM_001252204 NP_001239133    
NM_007293 NP_009224   A2M
NTR
ANATO
A2M_N
A2M_recep
A2M_comp
A2M_N_2

Related Sequences

 
mRNAGenPeptSwissProt
K00830 AAA36229 P0C0L4
K02404 AAA59651 P0C0L5
S81585 AAB36122 Q9UM89
K02403 AAB59537 P0C0L4
BC012372 AAH12372 Q96EG2
BC063289 AAH63289 Q6P4R1
BC144546 AAI44547 B2RUT6
BC146673 AAI46674 A6H8M8
BC146849 AAI46850 B2RUT6
BC151204 AAI51205 A7E2V2
BC171786 AAI71786 B7ZVZ6
BC172377 AAI72377  
AB209989 BAE06071 Q4LE82
AK293191 BAG56731 B4DDH0
AK304564 BAG65356 B4E344
AK293364 BAH11494 B7Z1F8
V00502 CAA23760 P0C0L4
XM_003960046 XP_003960095  
XM_003960047 XP_003960096  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens C4A NP_009224 H.sapiens C4B 721 Gene Info NP_001002029 99
R.norvegicus C4b 406161   NP_001002805 80
R.norvegicus C4a 24233   NP_113692 80
M.musculus C4b 12268 Gene Info NP_033910 77
M.musculus C4a 625018 Gene Info NP_035543 74

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta