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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. PKM, pyruvate kinase, muscle
Sequence ID:NM_001206796
NM_001206797
NM_001206798
NM_001206799
NM_002654
NM_182470
NM_182471
Entrez Gene ID:5315
Ensembl ID:ENSG00000067225

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:15q22Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:15: 72491371 - 72499107

 Exon Info From UCSC:
NM_002654
NM_182470
NM_182471

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2958817Full LengthBC012811pyruvate kinase, muscle
2964687Full LengthBC000481pyruvate kinase, muscle
3533876Full LengthBC007640pyruvate kinase, muscle
3859987Full LengthBC035198pyruvate kinase, muscle
4299213Full LengthBC007952pyruvate kinase, muscle
5296639Full LengthBC094767pyruvate kinase, muscle
3503708IncompleteBC019265pyruvate kinase, muscle
30558692IncompleteBC096823pyruvate kinase, muscle

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002645  NP_872271  NP_872270  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_001206796 NP_001193725      
NM_001206797 NP_001193726      
NM_001206798 NP_001193727      
NM_001206799 NP_001193728      
NM_002654 NP_002645 P14618 EC 2.7.1.40 PK
PK_C
NM_182470 NP_872270     PK
PK_C
NM_182471 NP_872271     PK
PK_C

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M23725 AAA36449 P14618 EC 2.7.1.40
M26252 AAA36672 P14618 EC 2.7.1.40
AF025439 AAC39559 P14618 EC 2.7.1.40
BC000481 AAH00481 P14618 EC 2.7.1.40
BC007640 AAH07640 P14618 EC 2.7.1.40
BC007952 AAH07952 P14618 EC 2.7.1.40
BC012811 AAH12811 P14618 EC 2.7.1.40
BC019265 AAH19265 Q8WUW7  
BC035198 AAH35198 P14618 EC 2.7.1.40
BC094767 AAH94767 Q504U3  
DQ892739 ABM83665    
EU176742 ABW03543    
EU832443 ACE86928    
EU832358 ACE87615    
AK222927 BAD96647 P14618 EC 2.7.1.40
AK312253 BAG35185 P14618 EC 2.7.1.40
AK092369 BAG52542 P14618 EC 2.7.1.40
AK294315 BAG57589 P14618 EC 2.7.1.40
AK297951 BAG60266 B4DNK4  
AK299413 BAG61395 B4DRT3  
AK300800 BAG62458 P14618 EC 2.7.1.40

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PKM2 NP_001193725 R.norvegicus Pkm2 25630   NP_445749 97
C.elegans F25H5.3 172744   NP_492458 59
C.elegans ZK593.1 177984   NP_502029 58
A.thaliana AT5G63680 836488   NP_201173 50
A.thaliana AT5G08570 830758   NP_196474 49
P.falciparum PFF1300w 3885761   XP_966251 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)