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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. FGFR2, Fibroblast growth factor receptor 2
Sequence ID:NM_022970
NM_000141
NM_001144917
NM_001144918
NM_001144916
NM_023029
NM_001144914
NM_001144915
NM_001144919
NM_001144913
RefSeqGene ID:NG_012449
Entrez Gene ID:2263
Ensembl ID:ENSG00000066468

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data


Associated Diseases (from OMIM)

DiseaseOther Genes
ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISFGFR1
APERT SYNDROME 
BEARE-STEVENSON CUTIS GYRATA SYNDROME 
BENT BONE DYSPLASIA SYNDROME 
CROUZON SYNDROME 
GASTRIC CANCER RISK AFTER H. PYLORI INFECTIONAPC
APC
CASP10
CDH1
ERBB2
IL1B
IL1RN
IRF1
KLF6
KLF6
KRAS
MUTYH
PIK3CA
PIK3CA
JACKSON-WEISS SYNDROMEFGFR1
LADD SYNDROMEFGF10
FGFR3
PFEIFFER SYNDROMEFGFR1
SAETHRE-CHOTZEN SYNDROMETWIST1
TWIST1
SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATION 

Cytogenetic Location (from UniGene)

Cytogenetic Location:10q26Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:10: 122483323 - 123357748

 Exon Info From UCSC:
NM_022970
NM_000141
NM_001144917
NM_001144918
NM_001144916
NM_001144914
NM_001144915
NM_001144919
NM_001144913

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5277896Full LengthBC039243fibroblast growth factor receptor 2
5264983IncompleteBC037338fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_075259  NP_000132  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000141 NP_000132 P21802 EC 2.7.10.1 ig
Pkinase_Tyr
NM_001144913 NP_001138385      
NM_001144914 NP_001138386      
NM_001144915 NP_001138387      
NM_001144916 NP_001138388      
NM_001144917 NP_001138389      
NM_001144918 NP_001138390      
NM_001144919 NP_001138391      
NM_022970 NP_075259     ig
Pkinase
I-set
V-set
Pkinase_Tyr
NM_023029 NP_075418      

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
M80634 AAA36147 P21802 EC 2.7.10.1
M97193 AAA52449 P21802 EC 2.7.10.1
M87770 AAA59470 P21802 EC 2.7.10.1
M87771 AAA59471 P21802 EC 2.7.10.1
M87772 AAA59472 P21802 EC 2.7.10.1
M55614 AAA61188 P21802 EC 2.7.10.1
U11814 AAA68514 P21802 EC 2.7.10.1
S41878 AAB19323 Q16888  
BC039243 AAH39243 P21802 EC 2.7.10.1
EF057068 ABO25744 D2CGD1  
EU826598 ACF47634 B5A960  
EU826599 ACF47635 B5A961  
EU826600 ACF47636 B5A962  
EU826601 ACF47637 B5A963  
HM437239 ADN43070 E2I6F9  
AB030073 BAA89296 P21802 EC 2.7.10.1
AB030074 BAA89297 P21802 EC 2.7.10.1
AB030075 BAA89298 P21802 EC 2.7.10.1
AB030076 BAA89299 P21802 EC 2.7.10.1
AB030077 BAA89300 P21802 EC 2.7.10.1
AB030078 BAA89301 P21802 EC 2.7.10.1
AB084153 BAC45037 P21802 EC 2.7.10.1
AK294026 BAG57383 P21802 EC 2.7.10.1
X52832 CAA37014 P21802 EC 2.7.10.1
X56191 CAA39654 P21802 EC 2.7.10.1
Z71929 CAA96492 P21802 EC 2.7.10.1

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens FGFR2 NP_075259 M.musculus Fgfr2 14183 Gene Info NP_034337 95
R.norvegicus Fgfr2 25022   NP_001103362 95
A.gambiae AgaP_AGAP003108 1273778   XP_562866 48
D.melanogaster htl 42160   NP_524394 43
D.melanogaster btl 39564   NP_729956 42

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)