Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. HMGCL, 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Sequence ID:NM_000191
RefSeqGene ID:NG_013061
Entrez Gene ID:3155
Ensembl ID:ENSG00000117305

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    b-cell, bone, bone marrow, brain, cartilage, cerebellum, cervix, colon, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p36.1-p35Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 24128376 - 24165110

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4178704Full LengthBC0105703-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000182  

Protein Infomation

NM_000191 NP_000182 P35914
EC HMGL-like
NM_001166059 NP_001159531      

Related Sequences

L07033 AAA92733 P35914 EC
BC010570 AAH10570 P35914
BT009792 AAP88794 P35914
DQ892083 ABM83009    
DQ895276 ABM86202    
FJ472654 ACK58684 B7UCC6  
GU433941 ADD21697 D3Y5K7  
AK313869 BAG36597 Q6IBC0  
AK122801 BAG53736 B1AK13  
AK300733 BAG62406 P35914 EC
CR456884 CAG33165 P35914

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens HMGCL NP_000182 R.norvegicus Hmgcl 79238   NP_077362 89
M.musculus Hmgcl 15356 Gene Info NP_032280 88
A.gambiae AgaP_AGAP008717 1275567   XP_314824 65
A.thaliana AT2G26800 817221   NP_565629 64
D.melanogaster CG10399 33978   NP_609089 61
C.elegans Y71G12B.10 171738   NP_490889 52
N.crassa NCU05419 3879390   XP_963242 47

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)