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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. C3, complement component 3
Sequence ID:NM_000064
RefSeqGene ID:NG_009557
Entrez Gene ID:718
Ensembl ID:ENSG00000125730

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
C3 DEFICIENCY 
HEMOLYTIC UREMIC SYNDROME, ATYPICAL 
MACULAR DEGENERATION, AGE-RELATED, 9 

Cytogenetic Location (from UniGene)

Cytogenetic Location:19p13.3-p13.2Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:19: 6677851 - 6683371

 Exon Info From UCSC:
NM_000064

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
40148091Full LengthBC150179complement component 3
40148812Full LengthBC150200complement component 3

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000055  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000064 NP_000055 P01024 A2M
NTR
ANATO
A2M_N
A2M_recep
A2M_comp
A2M_N_2

Related Sequences

 
mRNAGenPeptSwissProt
K02765 AAA85332 P01024
BC150179 AAI50180 P01024
BC150200 AAI50201 P01024
AK304071 BAG64978 B4E216

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens C3 NP_000055 R.norvegicus C3 24232   NP_058690 79
M.musculus C3 12266 Gene Info NP_033908 77

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta