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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. TOP1MT, topoisomerase (DNA) I, mitochondrial
Sequence ID:NM_001258446
Entrez Gene ID:116447
Ensembl ID:ENSG00000184428

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaSNPSNP: GeneViewSNP: VarViewAssembliesRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:8q24.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:8: 144391527 - 144417050

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5443410Full LengthBC052285topoisomerase (DNA) I, mitochondrial
6372930Full LengthBC071914topoisomerase (DNA) I, mitochondrial
4499637IncompleteBC027453topoisomerase (DNA) I, mitochondrial
5478964IncompleteBC044646topoisomerase (DNA) I, mitochondrial

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_443195  

Protein Infomation

NM_001258446 NP_001245375      
NM_001258447 NP_001245376      
NM_052963 NP_443195 Q969P6 EC Topoisom_I

Related Sequences

BC027453 AAH27453 Q8TBP3  
BC044646 AAH44646 Q969P6 EC
BC052285 AAH52285 Q969P6 EC
BC071914 AAH71914 Q969P6 EC
AF349017 AAL05624 Q969P6 EC
AK302372 BAG63694 B4DYD2  
AK303237 BAG64323 B4E061  
AK315913 BAH14284 B7Z9E8  
AK316380 BAH14751 B7ZAR5  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens TOP1MT NP_443195 R.norvegicus Top1mt 300029   NP_001002798 76
M.musculus Top1mt 72960 Gene Info NP_082680 74

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)