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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.

Gene Info

Gene Information For:Hs. POLE, polymerase (DNA directed), epsilon, catalytic subunit
Sequence ID:NM_006231
Entrez Gene ID:5426
Ensembl ID:ENSG00000177084

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

Cytogenetic Location (from UniGene)

Cytogenetic Location:12q24.3Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:12: 133263839 - 133264056

 Exon Info From UCSC:

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
100069130Full LengthBC172436polymerase (DNA directed), epsilon
3347229IncompleteBC007599polymerase (DNA directed), epsilon
4591469IncompleteBC087613polymerase (DNA directed), epsilon

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_006222  

Protein Infomation

NM_006231 NP_006222 Q07864 EC DNA_pol_B_exo

Related Sequences

S60080 AAA15448 Q07864 EC
U49356 AAA90924 Q07864 EC
L09561 AAC19148 Q07864 EC
AF128542 AAD45663 Q9UNE8  
BC007599 AAH07599 Q96IE1  
BC021559 AAH21559 Q8WU23  
BC087613 AAH87613 Q96IE1  
BC172436 AAI72436 Q07864 EC
AK025087 BAB15063 Q9H736  
AK093003 BAG52636 B3KS74  
AL080203 CAB45774 Q9Y4M6  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene Info Protein
H.sapiens POLE NP_006222 M.musculus Pole 18973 Gene Info NP_035262 91
A.gambiae AgaP_AGAP004615 1275917   XP_315205 58
D.melanogaster DNApol-epsilon 42758   NP_524462 58
C.elegans F33H2.5 173368   NP_493616 47
A.thaliana TIL1 837346   NP_172303 46
S.pombe cdc20 2540627   NP_596354 46
N.crassa NCU04548 3872087   XP_955939 46
S.cerevisiae POL2 855459   NP_014137 45
A.thaliana TIL2 817254   NP_180280 44

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)