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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. TSG101, tumor susceptibility gene 101
Sequence ID:NM_006292
RefSeqGene ID:NG_012138
Entrez Gene ID:7251
Ensembl ID:ENSG00000074319

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PHB
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
XRCC3
XRCC3

Cytogenetic Location (from UniGene)

Cytogenetic Location:11p15Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 18501859 - 18548472

NM_006292 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
193411850185918502181
3425811850317618503415
5827841850541618505618
7858761852403218524123
8779431852840318528469
94410671853108818531211
106812311853622418536387
123212971853764518537710
129813821854106518541149
138315501854832118548488

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3350039Full LengthBC002487tumor susceptibility gene 101

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_006283  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_006292 NP_006283 Q99816 UEV

Related Sequences

 
mRNAGenPeptSwissProt
U82130 AAC52083 Q99816
BC002487 AAH02487 Q99816
AY207473 AAO59169 Q86SI0
AY207474 AAO59170 Q86SI0
DQ892792 ABM83718  
DQ896039 ABM87038  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens TSG101 NP_006283 M.musculus Tsg101 22088 Gene Info NP_068684 95
R.norvegicus Tsg101 292925   NP_853659 94
D.melanogaster TSG101 39881   NP_524120 55
A.gambiae AgaP_AGAP005934 1276601   XP_315964 53
C.elegans tsg-101 182474   NP_500364 44
A.thaliana ELC 820419   NP_566423 35
A.thaliana ELC-Like 831232   NP_196890 31
S.cerevisiae STP22 850349   NP_009919 29

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta