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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HBB, Hemoglobin, beta
Sequence ID:NM_000518
RefSeqGene ID:NG_000007
Entrez Gene ID:3043
Ensembl ID:ENSG00000244734

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
DELTA-BETA THALASSEMIAHBG1
HBG2
HEINZ BODY ANEMIAHBA1
HBA1
HBA2
HBA2
SICKLE CELL ANEMIA 
THALASSEMIA, ALPHA-HBA1
HBA1
HBA2
HBA2
THALASSEMIA, HISPANIC GAMMA-DELTA-BETA 
THALASSEMIA-BETA, DOMINANT INCLUSION-BODY 

Cytogenetic Location (from UniGene)

Cytogenetic Location:11p15.5Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:11: 5246739 - 5248281

NM_000518 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
126152466955246955
26248452478065248028
48562652481595248300

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4292125Full LengthBC007075hemoglobin, beta

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000509  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_000518 NP_000509 P68871 Globin

Related Sequences

 
mRNAGenPeptSwissProt
M25079 AAA35597 P68871
M25113 AAA35966 P68871
M11428 AAA52633 P68871
AF117710 AAD19696 P68871
AF181832 AAF00488 Q9UK54
AF181989 AAF00489 P68871
BC007075 AAH07075 P68871
AF349114 AAK29639 P68871
AY136510 AAN11320 P68871
AY509193 AAR96398 P68871
DQ893159 ABM84085  
DQ896453 ABM87452  
EU176774 ABW03575  
EU694432 ACD39349 P68871
AK311825 BAG34767 P68871
V00497 CAA23756 P68871
V00500 CAA23759 P68871
CR536530 CAG38767 P68871
CR541913 CAG46711 P68871
AM392537 CAL37415  
AM393351 CAL38229  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HBB NP_000509 R.norvegicus Hbb 24440   NP_150237 82
M.musculus Beta-s 100503605   XP_003084764 80
M.musculus Hbb-b1 15129 Gene Info NP_032246 80
R.norvegicus LOC689064 689064   NP_001104739 79
R.norvegicus LOC100134871 100134871   NP_001106694 79
R.norvegicus Hbb-b1 361619   NP_942071 73

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta