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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. DCTN1, dynactin 1
Sequence ID:NM_001135040
NM_001135041
NM_001190836
NM_001190837
NM_004082
NM_023019
NR_033935
RefSeqGene ID:NG_008735
Entrez Gene ID:1639
Ensembl ID:ENSG00000204843

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, peripheral nervous system, pineal gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
AMYOTROPHIC LATERAL SCLEROSISANG
NEFH
PRPH
SOD1
NEUROPATHY, DISTAL HEREDITARY MOTOR, TYPE VIIB 
PERRY SYNDROME 

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p13Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 74588281 - 74592028

 Exon Info From UCSC:
NM_001135040
NM_001135041
NM_001190836
NM_001190837
NM_004082
NM_023019

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
4817849Full LengthBC071583dynactin 1 (p150, glued homolog, Drosophila)
3937065IncompleteBC006163dynactin 1 (p150, glued homolog, Drosophila)

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_004073  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_001135040 NP_001128512    
NM_001135041 NP_001128513    
NM_001190836 NP_001177765    
NM_001190837 NP_001177766    
NM_004082 NP_004073 Q14203 CAP_GLY
NM_023019 NP_075408    

Related Sequences

 
mRNAGenPeptSwissProt
U73799 AAB52575 Q6LCB2
U90445 AAD00701 O95654
BC071583 AAH71583 Q6IQ37
BT006758 AAP35404 Q14203
EU831684 ACE86518  
EU831597 ACE87197  
AB209625 BAD92862 Q59F36
AK297286 BAG59757 B4DM45
X98801 CAA67333 Q14203
BX640799 CAE45882 Q6MZZ3
BX647972 CAH10572 Q6AWB1
BX647925 CAH10575 Q6AWB3

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens DCTN1 NP_001177766 M.musculus Dctn1 13191 Gene Info NP_031861 97
R.norvegicus Dctn1 29167   NP_077044 97
A.gambiae AgaP_AGAP004194 1274028   XP_313086 38
D.melanogaster Gl 39536   NP_524061 36
N.crassa NCU03483 3871917   XP_955770 30
C.elegans dnc-1 177987   NP_502033 30

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)

BioCarta Pathways
Pathway information courtesy of BioCarta