Skip Navigation
NCI banner National Cancer Institute U.S. National Institutes of Health National Cancer Institute
Genes
  • Gene Tools
Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. HADHA, hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
Sequence ID:NM_000182
RefSeqGene ID:NG_007121
Entrez Gene ID:3030
Ensembl ID:ENSG00000084754

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
FATTY LIVER, ACUTE, OF PREGNANCY 
TRIFUNCTIONAL PROTEIN DEFICIENCYHADHB

Cytogenetic Location (from UniGene)

Cytogenetic Location:2p23Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:2: 26416181 - 26418712

 Exon Info From UCSC:
NM_000182

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
2966432Full LengthBC009235hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_000173  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_000182 NP_000173 P40939 EC 1.1.1.211
EC 4.2.1.17
ECH
3HCDH
3HCDH_N

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
U04627 AAA56664 P40939 EC 1.1.1.211
EC 4.2.1.17
BC009235 AAH09235 P40939 EC 1.1.1.211
EC 4.2.1.17
DQ892776 ABM83702    
DQ896023 ABM87022    
GU727642 ADU87643 E9KL44  
D16480 BAA03941 P40939 EC 1.1.1.211
EC 4.2.1.17
AK313027 BAG35861 P40939 EC 1.1.1.211
EC 4.2.1.17
AK293398 BAG56906 B4DDZ5  
AK299258 BAG61288 B4DRH6  
AK302532 BAG63804 B4DYP2  

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens HADHA NP_000173 M.musculus Hadha 97212 Gene Info NP_849209 87
R.norvegicus Hadha 170670   NP_570839 85
A.gambiae AgaP_AGAP007784 1278181   XP_317731 57
D.melanogaster CG4389 34276   NP_609299 57
C.elegans T08B2.7 172310   NP_491789 54
C.elegans ech-1 180037   NP_506810 52
A.thaliana AIM1 829022   NP_194630 35

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)