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Cancer Genome Characterization Initiative

Visit the database of genomic characterization data for multiple tumor types.


Gene Info

Gene Information For:Hs. ICMT, Isoprenylcysteine carboxyl methyltransferase
Sequence ID:NM_012405
Entrez Gene ID:23463
Ensembl ID:ENSG00000116237

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, ear, embryonic tissue, endocrine, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, pineal gland, placenta, pooled tissue, prostate, retina, skin, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Cytogenetic Location (from UniGene)

Cytogenetic Location:1p36.21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:1: 6281252 - 6281738

NM_012405 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
3407062812546285321
4071428862919616292178
4289445862935336293702
4459454762949456295033
4548481562957766296043

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
5245125Full LengthBC028168isoprenylcysteine carboxyl methyltransferase
3904144IncompleteBC017037isoprenylcysteine carboxyl methyltransferase

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_036537  

Protein Infomation

RefSeq
mRNAProteinSwissProtEnzymePfam
NM_012405 NP_036537 O60725 EC 2.1.1.100 ICMT

Related Sequences

 
mRNAGenPeptSwissProtEnzyme
AF064084 AAC16554 O60725 EC 2.1.1.100
AF173157 AAF89831 Q9NRT1  
BC028168 AAH28168 O60725 EC 2.1.1.100
AK092890 BAG52623 B3KS61  
CR541671 CAG46472 O60725 EC 2.1.1.100
CR541711 CAG46512 O60725 EC 2.1.1.100

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens ICMT NP_036537 M.musculus Icmt 57295 Gene Info NP_598549 96
R.norvegicus Icmt 170818   NP_579844 95
D.melanogaster ste14 39478   NP_648623 52
A.gambiae AgaP_AGAP001310 1281867   XP_321837 50
A.thaliana ATSTE14B 830731   NP_568191 46
A.thaliana STE14A 832396   NP_197723 46
C.elegans M01E11.1 187374   NP_491635 46
C.elegans F21F3.3 172106   NP_491473 43
S.cerevisiae STE14 852019   NP_010698 42
N.crassa NCU00034 3873159   XP_957021 42
S.pombe mam4 2542982   NP_593263 41

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)