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Cancer Genome Characterization Initiative

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Gene Info

Gene Information For:Hs. PHB, Prohibitin
Sequence ID:NM_002634
RefSeqGene ID:NG_023046
Entrez Gene ID:5245
Ensembl ID:ENSG00000167085

Database Links

UniGeneEntrez GeneOMIMEnsembl GeneHPRDVegaDTPSNPSNP: GeneViewSNP: VarViewAssembliesCancer AberrationsRNAi

Gene Expression Data

  • This gene is found in these cDNA libraries from the following tissue types:
    adrenal cortex, b-cell, bone, bone marrow, brain, cartilage, cerebellum, cerebrum, cervix, colon, embryonic tissue, endocrine, esophagus, eye, fetus, gastrointestinal tract, heart, kidney, liver, lung, lymph node, lymphoreticular, mammary gland, muscle, nervous, ovary, pancreas, pancreatic islet, parathyroid, peripheral nervous system, pineal gland, pituitary gland, placenta, pooled tissue, prostate, retina, salivary gland, skin, soft tissue, spleen, stem cell, stomach, synovium, t-cell, testis, thymus, thyroid, uncharacterized tissue, uterus, vascular
  • SAGE Anatomic Viewer
  • SAGE Digital Northern

  • Monochromatic SAGE/cDNA Virtual Northern

  • Two-dimensional array displays (similar expression pattern in NCI60 microarray data or SAGE data)

Associated Diseases (from OMIM)

DiseaseOther Genes
BREAST CANCERAKT1
ATM
BARD1
BRCA1
BRCA2
BRIP1
CASP8
CDH1
CHEK2
CHEK2
HMMR
KRAS
NQO2
NQO2
PALB2
PIK3CA
PIK3CA
PPM1D
RAD51
RAD54L
RB1CC1
SLC22A18
TP53
TP53
TSG101
XRCC3
XRCC3

Cytogenetic Location (from UniGene)

Cytogenetic Location:17q21Mitelman Breakpoint Data

Chromosomal Position (from UCSC)

Chromosomal Position:17: 47481546 - 47492242

NM_002634 exon info from UCSC:

Transcript StartTranscript EndChromosomal Start Chromosomal End
111474748141947482565
114812434748412047484215
124413604748640347486519
136115034748669247486834
150416654748903947489200
166617804749053847490652
178118264749219647492241

Full-Length MGC Clones for This Gene

IMAGE IdStatusAccession GenBank Def Line
3010198Full LengthBC013401prohibitin
30557359Full LengthBC095460prohibitin

Protein Similarities Based on Shared Motif Content

Find gene products sharing protein motifs with:  NP_002625  

Protein Infomation

RefSeq
mRNAProteinSwissProtPfam
NM_002634 NP_002625 P35232 Band_7

Related Sequences

 
mRNAGenPeptSwissProt
S85655 AAB21614 P35232
BC013401 AAH13401 P35232
BC095460 AAH95460 P35232
BT007411 AAP36079 P35232
AY577780 AAS88903 Q6PUJ7
AK223181 BAD96901 Q53FV0
AK290766 BAF83455 A8K401
AK312649 BAG35532 A8K401
AK302258 BAG63609 B4DY47
CR541706 CAG46507 Q6FHP5
AM393620 CAL38496 P35232

Homologs (from HomoloGene)
Note: Both orthologs and paralogs are included.
Organism Symbol Protein Homolog Similarity
(% aa unchanged)
Organism Symbol Entrez
Gene
Gene Info Protein
H.sapiens PHB NP_002625 M.musculus Phb 18673 Gene Info NP_032857 100
A.gambiae AgaP_AGAP009323 1271235   XP_309992 76
D.melanogaster l(2)37Cc 49168   NP_724165 75
C.elegans phb-1 171768   NP_490929 66
N.crassa NCU08946 3876951   XP_960813 59
A.thaliana PHB3 834077   NP_198893 56
A.thaliana PHB4 822347   NP_189364 56
S.pombe SPAC1782.06c 2542354   NP_594713 55
S.cerevisiae PHB1 853033   NP_011648 54
P.falciparum PF08_0006 2655455   XP_001349234 50

Gene Ontology
Gene classification by the European Bioinformatics Institute, as recorded in GOA (GO Annotation@EBI)